SEPHS1 and DEPDC7

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		SEPHS1	DEPDC7
Description		selenophosphate synthetase 1	DEP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Membrane	Cellular_component
	Molecular Function	Nucleotide Binding Selenide, Water Dikinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Molecular_function
	Biological Process	Selenocysteine Biosynthetic Process Protein Modification Process	Biological_process Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Metabolite levels ( 23823483) Schizophrenia x sex interaction ( 34099189)	Lung cancer in ever smokers ( 28604730)
Interacting Genes		18 interacting genes: CDCA4 CRMP1 DEPDC7 ERG28 GBP2 IGSF21 PLAGL2 QRICH1 SAT1 SLC35F6 SPACA9 UNC119 XAF1 ZBTB25 ZNF202 ZNF276 ZNF474 ZNF526	2 interacting genes: GTF2B SEPHS1
Entrez ID		22929	91614
HPRD ID		02944	11280
Ensembl ID		ENSG00000086475	ENSG00000121690
Uniprot IDs		P49903	Q96QD5
PDB IDs		3FD5 3FD6
Enriched GO Terms of Interacting Partners?			Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II Core Complex Assembly Selenocysteine Biosynthetic Process Selenide, Water Dikinase Activity Positive Regulation Of Core Promoter Binding Selenocysteine Metabolic Process Germinal Vesicle Viral Transcription Meiotic Sister Chromatid Cohesion Positive Regulation Of Transcription Regulatory Region DNA Binding Transcription Preinitiation Complex Cell Division Site Acetyltransferase Activity Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding Transcription Factor TFIID Complex Protein Acetylation Nuclear Thyroid Hormone Receptor Binding TBP-class Protein Binding Histone Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Serine Family Amino Acid Metabolic Process Condensed Chromosome Sister Chromatid Cohesion Protein-DNA Complex RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of DNA Binding Positive Regulation Of Binding Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Amino Acid Biosynthetic Process Promoter-specific Chromatin Binding Protein Modification Process DNA-templated Transcription Initiation Transferase Activity Spindle Assembly RNA Polymerase II Transcription Regulator Complex Acyltransferase Activity Viral Process Spindle Organization Kinetochore DNA-binding Transcription Factor Binding Protein-DNA Complex Assembly Alpha-amino Acid Metabolic Process
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