COX17 and PPBP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COX17	PPBP
Description		cytochrome c oxidase copper chaperone COX17	pro-platelet basic protein
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space	Extracellular Region Extracellular Space Platelet Alpha Granule Platelet Alpha Granule Lumen Tertiary Granule Lumen
	Molecular Function	Copper Ion Binding Protein Binding Enzyme Activator Activity Copper Chaperone Activity Metal Ion Binding Cuprous Ion Binding	Cytokine Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Copper Ion Transport Heart Development Positive Regulation Of Cell Population Proliferation Mitochondrial Cytochrome C Oxidase Assembly Positive Regulation Of Cytochrome-c Oxidase Activity	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Killing Of Cells Of Another Organism Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide D-glucose Transmembrane Transport
Pathways		Mitochondrial protein import Complex IV assembly	Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ethanesulfonic acid Copper
Diseases
GWAS		Tau burden ( 33426524)	Metabolite levels ( 22916037)
Interacting Genes		12 interacting genes: COPS6 EEF1A1 ERG28 HADHB KATNAL1 KRTAP10-8 LRIF1 PPBP RBM48 TP53 UBC UNC119	32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		10063	5473
HPRD ID		05314	07171
Ensembl ID		ENSG00000138495	ENSG00000163736
Uniprot IDs		C9J8T6 Q14061	P02775
PDB IDs		2L0Y 2LGQ 2RN9 2RNB	1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?		Glial Cell Apoptotic Process Negative Regulation Of Glial Cell Proliferation Disordered Domain Specific Binding Glial Cell Proliferation	Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Antimicrobial Humoral Response Granulocyte Chemotaxis Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Granulocyte Migration Humoral Immune Response Cytokine Activity Killing Of Cells Of Another Organism Cell Migration Cytokine-mediated Signaling Pathway Mononuclear Cell Migration Cell Motility Cell Killing CXCR Chemokine Receptor Binding Inflammatory Response Eosinophil Chemotaxis Defense Response To Symbiont Eosinophil Migration Defense Response Defense Response To Other Organism Immune System Process Neutrophil Chemotaxis Immune Response CCR Chemokine Receptor Binding Chemokine Receptor Binding Neutrophil Migration Response To External Biotic Stimulus Response To Other Organism Cell-cell Signaling G Protein-coupled Receptor Signaling Pathway Signaling Cell Communication T Cell Chemotaxis Dendritic Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling CXCR3 Chemokine Receptor Binding Dendritic Cell Migration Lymphocyte Chemotaxis Neutrophil Activation Negative Regulation Of Cellular Extravasation T Cell Migration Positive Regulation Of T Cell Migration Extracellular Space
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