COX17 and PPBP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COX17	PPBP
Gene Name		COX17 cytochrome c oxidase copper chaperone	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Copper Ion Binding Copper Chaperone Activity	Glucose Transmembrane Transporter Activity Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Copper Ion Transport Brain Development Heart Development	Leukocyte Migration Involved In Inflammatory Response Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Glucose Transport Platelet Activation Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Positive Regulation Of Cell Division Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Mitochondrial protein import	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs			Ethanesulfonic Acid
Diseases
GWAS			Metabolite levels ( 22916037)
Protein-Protein Interactions		10 interactors: C14orf1 COPS6 EEF1A1 HADHB KATNAL1 LRIF1 PPBP RBM48 TP53 UNC119	21 interactors: CELF1 CMTM6 COPG1 COPS7A COX17 CSNK2A1 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		10063	5473
HPRD ID		05314	07171
Ensembl ID
Uniprot IDs		Q14061	P02775
PDB IDs		2L0Y 2LGQ 2RN9 2RNB	1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?			Interleukin-8-mediated Signaling Pathway Chemotaxis Response To External Stimulus Dendritic Cell Chemotaxis Dendritic Cell Migration Locomotion Cell Chemotaxis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Receptor Internalization Movement Of Cell Or Subcellular Component Vesicle Docking Involved In Exocytosis Negative Regulation Of Neutrophil Apoptotic Process Basolateral Protein Localization Chemokine-mediated Signaling Pathway Golgi Vesicle Transport Vesicle Docking Neutrophil Mediated Killing Of Gram-positive Bacterium Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Membrane Docking Post-Golgi Vesicle-mediated Transport Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Defense Response Leukocyte Chemotaxis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endopeptidase Activity Cell Migration Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Membrane Organization Regulation Of Peptidase Activity Vesicle-mediated Transport Immune System Process Negative Regulation Of Mitochondrial Membrane Potential Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Cell Motility Regulation Of Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Intracellular Transport Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Mitral Valve Development
Tagcloud ?		affecting alleles appear budding cerevisae connection deadenylation decapping decay defective degradation dhh1 edc1 initiated machinery mrnas multicopy pat1 pat1delta promote promoted ribosome saccharomyces stm1 stm1delta translation understand upstream working	10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Difference) ?		affecting alleles appear budding cerevisae connection deadenylation decapping decay defective degradation dhh1 edc1 initiated machinery mrnas multicopy pat1 pat1delta promote promoted ribosome saccharomyces stm1 stm1delta translation understand upstream working	10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Intersection) ?