COX17 and HADHB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		COX17	HADHB
Description		cytochrome c oxidase copper chaperone COX17	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space	Nucleoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid
	Molecular Function	Copper Ion Binding Protein Binding Enzyme Activator Activity Copper Chaperone Activity Metal Ion Binding Cuprous Ion Binding	RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-containing Complex Binding Acetyl-CoA C-myristoyltransferase Activity LncRNA Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Copper Ion Transport Heart Development Positive Regulation Of Cell Population Proliferation Mitochondrial Cytochrome C Oxidase Assembly Positive Regulation Of Cytochrome-c Oxidase Activity	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Gene Expression Cellular Response To Lipopolysaccharide
Pathways		Mitochondrial protein import Complex IV assembly	Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
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Diseases
GWAS		Tau burden ( 33426524)
Interacting Genes		12 interacting genes: COPS6 EEF1A1 ERG28 HADHB KATNAL1 KRTAP10-8 LRIF1 PPBP RBM48 TP53 UBC UNC119	18 interacting genes: ANXA7 APP CDC42 CDKN1A CEBPA CHCHD4 COX17 DDX17 GRB7 HSD17B10 HSPB2 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K UBC
Entrez ID		10063	3032
HPRD ID		05314	00887
Ensembl ID		ENSG00000138495	ENSG00000138029
Uniprot IDs		C9J8T6 Q14061	F5GZQ3 P55084
PDB IDs		2L0Y 2LGQ 2RN9 2RNB	5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?		Glial Cell Apoptotic Process Negative Regulation Of Glial Cell Proliferation Disordered Domain Specific Binding Glial Cell Proliferation	Mitochondrial Intermembrane Space
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