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OTUD4 and STAT1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
OTUD4
STAT1
Gene Name
OTU deubiquitinase 4
signal transducer and activator of transcription 1, 91kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Nuclear Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Molecular Function
Ubiquitin-specific Protease Activity
Poly(A) RNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Signal Transducer Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
CCR5 Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Proteolysis
Protein K48-linked Deubiquitination
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Apoptotic Process
JAK-STAT Cascade
Response To Nutrient
Blood Circulation
Response To Mechanical Stimulus
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Insulin Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Negative Regulation Of Macrophage Fusion
Cellular Response To Interferon-beta
Response To Drug
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Renal Tubule Development
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways
Signaling by PDGF
Signaling by FGFR in disease
ISG15 antiviral mechanism
Interferon Signaling
Cytokine Signaling in Immune system
Antiviral mechanism by IFN-stimulated genes
Signaling by SCF-KIT
Downstream signal transduction
Signaling by FGFR1 mutants
Signaling by FGFR mutants
Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
5 interactors:
EXOSC8
REL
STAT1
TCF4
UBC
103 interactors:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DOT1L
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
ERBB2
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FYN
GFAP
GNB2L1
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTBN1
SRC
STAT2
STAT3
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBC
UBE2I
VDR
XPO1
ZNF467
Entrez ID
54726
6772
HPRD ID
11033
02777
Ensembl ID
ENSG00000164164
ENSG00000115415
Uniprot IDs
G3V0I6
Q01804
J3KPM9
P42224
PDB IDs
1BF5
1YVL
2KA6
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
I-kappaB Kinase/NF-kappaB Signaling
Glycogen Metabolic Process
Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Positive Regulation Of Cellular Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Macrophage Fusion
Response To Cytokine
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Energy Reserve Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Glucose Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Catenin Import Into Nucleus
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cellular Response To Growth Factor Stimulus
Response To Organic Substance
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Response To Organic Substance
Defense Response
Innate Immune Response
Response To Cytokine
Immune Response
Immune System Process
Cell Surface Receptor Signaling Pathway
Cellular Response To Cytokine Stimulus
Cytokine-mediated Signaling Pathway
Signal Transduction
Regulation Of Immune Response
Positive Regulation Of Cellular Metabolic Process
Signaling
Response To Stress
Regulation Of Immune System Process
Cell Communication
Cellular Response To Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Protein Metabolic Process
Response To Stimulus
Positive Regulation Of Metabolic Process
Protein Autophosphorylation
Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Innate Immune Response
Regulation Of Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Signaling
Response To External Stimulus
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Peptidyl-amino Acid Modification
Immune Response-regulating Signaling Pathway
Viral Process
Fc Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Peptidyl-tyrosine Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Metabolic Process
Regulation Of Phosphorus Metabolic Process
Tagcloud
?
augment
augments
bait
cbp
coactivator
coil
coiled
enhances
except
hybrid
ifngamma
instead
interactor
interacts
interestingly
intrinsic
lacks
myc
nmi
potentiate
recruitment
reveal
screen
stat2
stat5
stat5b
stats
yeast
Tagcloud (Difference)
?
augment
augments
bait
cbp
coactivator
coil
coiled
enhances
except
hybrid
ifngamma
instead
interactor
interacts
interestingly
intrinsic
lacks
myc
nmi
potentiate
recruitment
reveal
screen
stat2
stat5
stat5b
stats
yeast
Tagcloud (Intersection)
?