OTUD4 and ALKBH3

Number of citations of the paper that reports this interaction (PubMedID 25944111)
48

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		OTUD4	ALKBH3
Description		OTU deubiquitinase 4	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Molecular Adaptor Activity K63-linked Deubiquitinase Activity	Protein Binding Ferrous Iron Binding Oxidoreductase Activity L-ascorbic Acid Binding Oxidative RNA Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity MRNA N1-methyladenosine Dioxygenase Activity
	Biological Process	Immune System Process DNA Alkylation Repair Proteolysis Negative Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Deubiquitination Protein K27-linked Ubiquitination Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway	DNA Repair DNA Alkylation Repair DNA Damage Response Cell Population Proliferation Negative Regulation Of Cytoplasmic Translation
Pathways			ALKBH3 mediated reversal of alkylation damage
Drugs			Ascorbic acid
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 30696823) Femur bone mineral density x serum urate levels interaction ( 34046847) Morning person ( 30696823)
Interacting Genes		12 interacting genes: ALKBH3 EXOSC8 MAVS PFKFB3 REL STAT1 TCF4 UBC USP7 VDR ZBTB7A ZNF655	13 interacting genes: AK8 FBXO7 GLRX3 GOLGA2 GSK3A IKZF1 LNX1 OTUD4 SRPK1 SRPK2 TRIM55 TRIM63 ZDHHC17
Entrez ID		54726	221120
HPRD ID		11033	16793
Ensembl ID		ENSG00000164164	ENSG00000166199
Uniprot IDs		Q01804	Q96Q83
PDB IDs			2IUW 8JNK 8JNR 9NCZ
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Interferon-alpha Production Histone Acetyltransferase Binding DNA Alkylation Repair Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Interferon-beta Production Brain Renin-angiotensin System TORC1 Signaling Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Transcription Corepressor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding MRNA Transcription Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Lithocholic Acid Binding Regulation Of Peroxisome Organization Positive Regulation Of IP-10 Production MRNA N1-methyladenosine Dioxygenase Activity Nucleobase-containing Compound Metabolic Process Nucleoplasm 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II NF-kappaB Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Metabolic Process	Protein Modification Process Protein Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Transferase Activity Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Innate Immune Response Protein Modification By Small Protein Conjugation Cytoplasm Defense Response To Other Organism Immune System Process Defense Response To Symbiont Positive Regulation Of Viral Genome Replication Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Muscle System Process Regulation Of Neuron Apoptotic Process Ubiquitin-protein Transferase Activity Kinase Activity Response To Other Organism Positive Regulation Of Viral Process Identical Protein Binding Regulation Of Carbohydrate Catabolic Process Protein Polyubiquitination Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Viral Genome Replication Immune Response Negative Regulation Of Viral Process Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Microtubule Response To External Biotic Stimulus Protein Serine Kinase Activity Lewy Body Core Regulation Of Protein K48-linked Deubiquitination
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