PAF1 and RERE

		PAF1	RERE
Description		PAF1 component of Paf1/RNA polymerase II complex	arginine-glutamic acid dipeptide repeats
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition	Chromatin Remodeling Regulation Of DNA-templated Transcription Cerebellum Development Cerebellar Purkinje Cell Layer Maturation Cerebellar Granule Cell Precursor Proliferation Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Branching Morphogenesis Of A Nerve Dendrite Morphogenesis
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune thyroid disease ( 32581359) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Daytime nap ( 33568662) Depression ( 29700475) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Feeling miserable ( 29500382) Femoral neck bone mineral density ( 22504420) Fish- and plant-related diet ( 32066663) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) Hippocampal volume in normal cognition ( 29274321) Loneliness ( 31518406) Lymphocyte count ( 32888494 27863252) Major depressive disorder ( 27479909) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Optic cup area ( 25631615 28073927) Parkinson's disease ( 32201043) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33536424) Systolic blood pressure ( 30578418) Tonsillectomy ( 28928442 27182965) Total body bone mineral density ( 29304378) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Upper eyelid morphology ( 29921221) Vertical cup-disc ratio ( 25241763 20548946) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)
Interacting Genes		17 interacting genes: CEBPA ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3	25 interacting genes: ALG13 ATN1 CBFA2T2 CCDC120 ECM1 EFEMP1 EFEMP2 EHMT2 H3C14 KAT6A KRTAP12-4 KRTAP4-12 KRTAP6-2 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 SNRPC TRIM22 TRIP6 VHL ZMYND8
Entrez ID		54623	473
HPRD ID		10140	05566
Ensembl ID		ENSG00000006712	ENSG00000142599
Uniprot IDs		Q8N7H5	Q9P2R6
PDB IDs		4M6T 5ZYQ 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	2YQK
Enriched GO Terms of Interacting Partners?		MSL Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Chromatin Binding Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation DNA Binding Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation Factor Complex Nucleolus NuA4 Histone Acetyltransferase Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Chromosome Protein Homodimerization Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Kinase C Signaling Histone H2B Ubiquitin Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Elongation Positive Regulation Of Gene Expression, Epigenetic Cerebellar Purkinje Cell Layer Maturation Response To Vitamin B2 C/EBP Complex	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Cajal Body Protein Binding Developmental Process Zinc Ion Binding Camera-type Eye Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Extracellular Matrix Structural Constituent Regulation Of Gene Expression Epidermal Growth Factor Receptor Binding Eye Development DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Forebrain Generation Of Neurons Histone H3K56 Methyltransferase Activity Positive Regulation Of Smooth Muscle Cell-matrix Adhesion N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Endoplasmic Reticulum Tubular Network Maintenance
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