SOX10 and DLX5

Number of citations of the paper that reports this interaction (PubMedID 16582099)
44

Data Source:
HPRD (two hybrid, in vitro)

		SOX10	DLX5
Description		SRY-box transcription factor 10	distal-less homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane	Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Neuroblast Proliferation Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Cell Differentiation Melanocyte Differentiation Positive Regulation Of Myelination Developmental Process Lacrimal Gland Development Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Stem Cell Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Cellular Response To Xenobiotic Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Head Development Face Morphogenesis Bone Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of CDH19 Expression and Function Regulation of MITF-M-dependent genes involved in pigmentation Transcriptional and post-translational regulation of MITF-M expression and activity	Regulation of RUNX2 expression and activity Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases		Waardenburg syndrome (WS) 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Mean spheric corpuscular volume ( 32888494)	Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning vs. evening chronotype ( 26835600)
Interacting Genes		44 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX CTNNB1 DAZAP2 DLX5 EGR2 ERG EXOC5 GSK3B HHEX HIVEP1 HNF1B HOXA3 HOXC4 HSF4 JUN MAGED1 MAPK1 MEOX1 NFIC NFIX NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 RCAN1 RSPH1 SP1 SUMO1 SUMO2 SUMO3 TCF12 TIAM1 UBE2I UTF1	9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		6663	1749
HPRD ID		03752	02492
Ensembl ID		ENSG00000100146	ENSG00000105880
Uniprot IDs		P56693	P56178 Q53Y73
PDB IDs			2DJN 4RDU
Enriched GO Terms of Interacting Partners?		HMG Box Domain Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding System Development Negative Regulation Of RNA Metabolic Process Animal Organ Development Developmental Process Animal Organ Morphogenesis Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Embryonic Organ Morphogenesis Nucleoplasm Ubiquitin Protein Ligase Binding Cell Fate Specification Transcription Coregulator Binding Protein Sumoylation	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Morphogenesis Of A Branching Structure Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Oligodendrocyte Differentiation Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Positive Regulation Of Multicellular Organismal Process Activation Of Meiosis Animal Organ Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Regulation Of Multicellular Organismal Process Transcription Cis-regulatory Region Binding Regionalization Regulation Of Gene Expression Regulation Of Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Binding Regulation Of Primary Metabolic Process Mammary Gland Epithelium Development Odontogenesis Mesenchymal Cell Apoptotic Process Enteric Nervous System Development Regulation Of Gliogenesis Cartilage Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Glial Cell Differentiation Regulation Of Multicellular Organismal Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Regulation Of Neurogenesis
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