CSH2 and PTPN12

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		CSH2	PTPN12
Gene Name		chorionic somatomammotropin hormone 2	protein tyrosine phosphatase, non-receptor type 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Podosome Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection
	Molecular Function	Hormone Activity Metal Ion Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process		Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: POLR2A PTPN12 SMAD2 SMAD3 SMAD4 SMAD9	37 interactors: ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR FLT3 GRB2 IFT20 INSR JAK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PXN RBM19 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		1443	5782
HPRD ID		06688	02513
Ensembl ID		ENSG00000213218	ENSG00000127947
Uniprot IDs		A6NIT4 B1A4H9 P01243	A4D1C5 B4E105 E9PBR5 Q05209
PDB IDs		1Z7C
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Kidney Development Somatic Stem Cell Maintenance Renal System Development Endoderm Development Primary MiRNA Processing Embryonic Pattern Specification Urogenital System Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Mesoderm Development Cellular Response To Growth Factor Stimulus Stem Cell Maintenance Response To Growth Factor Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Nodal Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Embryonic Foregut Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Foregut Morphogenesis Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Paraxial Mesoderm Development Tube Development Mesenchyme Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Cell Differentiation Pericardium Development Signal Transduction Involved In Regulation Of Gene Expression Anterior/posterior Pattern Specification Stem Cell Development Regulation Of Binding	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Adhesion Protein Autophosphorylation Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Response To Organonitrogen Compound Cell Activation Regulation Of Protein Kinase Activity Blood Coagulation Peptidyl-tyrosine Autophosphorylation Hemostasis Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide Signal Transduction Regulation Of Kinase Activity Regulation Of MAPK Cascade Innate Immune Response Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Phosphorylation Cell Communication Regulation Of MAP Kinase Activity Peptidyl-amino Acid Modification Response To Hormone Cellular Response To Growth Factor Stimulus Platelet Activation Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Locomotion Response To Peptide Hormone Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Kinase Activity Protein Phosphorylation Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Response To Peptide
Tagcloud ?		activates associates autoinhibition construct delta domain epor erythropoietin fc intramolecular kd merely phosphotyrosine ptp1 ptp1c ptpase py py309 py429 r136k r30k r33e recruiting riib1 serves shp truncation	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		activates associates autoinhibition construct delta domain epor erythropoietin fc intramolecular kd merely phosphotyrosine ptp1 ptp1c ptpase py py309 py429 r136k r30k r33e recruiting riib1 serves shp truncation	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?