ATOH1

Description		atonal bHLH transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neuron Migration Transcription By RNA Polymerase II Notch Signaling Pathway Nervous System Development Axon Guidance Central Nervous System Development Brain Development Sensory Organ Development Negative Regulation Of Gliogenesis Central Nervous System Neuron Differentiation Cerebral Cortex Development Cell Differentiation Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Auditory Receptor Cell Fate Specification Auditory Receptor Cell Fate Determination Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment System Development Inner Ear Development Axon Development Neuroblast Migration Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Inner Ear Receptor Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Metabolite levels ( 23823483)
Novel Interacting Genes		1 novel interacting genes: POLE2
Interacting Genes		2 interacting genes: HMGB1 HUWE1
Entrez ID		474
HPRD ID		03270
Ensembl ID		ENSG00000172238
Uniprot IDs		Q92858
PDB IDs
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Repair DNA Metabolic Process Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity DNA Damage Response Ficolin-1-rich Granule Lumen Secretory Granule Lumen Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Autophagy Negative Regulation Of Apoptotic Cell Clearance C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Histone Ubiquitin Ligase Activity Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of DNA-templated Transcription Initiation Cellular Response To Stress Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Myeloid Progenitor Cell Differentiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Supercoiled DNA Binding Positive Regulation Of Dendritic Cell Differentiation Regulation Of Endodeoxyribonuclease Activity Neutrophil Clearance Epsilon DNA Polymerase Complex Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway DNA Geometric Change Regulation Of Glycogen Catabolic Process Regulation Of Autophagy Bubble DNA Binding Regulation Of Apoptotic Cell Clearance DNA Binding Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Nucleic Acid Metabolic Process Regulation Of Toll-like Receptor 9 Signaling Pathway DNA Topological Change Endothelial Cell Chemotaxis Error-prone Translesion Synthesis Positive Regulation Of Type 2 Mitophagy RAGE Receptor Binding Regulation Of Mitochondrial Fusion
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