SOX12 and SRM

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOX12	SRM
Gene Name		SRY (sex determining region Y)-box 12	spermidine synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Protein-DNA Complex	Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity DNA Binding	Spermidine Synthase Activity Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spinal Cord Development Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein-DNA Complex Assembly	Polyamine Metabolic Process Spermidine Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of polyamines Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: POLD2 SMAD4 SRM	2 interactors: SOX12 TERF1
Entrez ID		6666	6723
HPRD ID		09056	01692
Ensembl ID		ENSG00000177732	ENSG00000116649
Uniprot IDs		O15370	P19623
PDB IDs			2O05 2O06 2O07 2O0L 3RW9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Nephrogenic Mesenchyme Morphogenesis Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Endocardial Cell Differentiation Spermidine Biosynthetic Process Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Heart Valve Formation Metanephric Mesenchyme Development Endocardial Cushion Formation Endocardium Development Atrioventricular Valve Morphogenesis Nucleotide-excision Repair, DNA Gap Filling Polyamine Biosynthetic Process Regulation Of Hair Cycle Endocardial Cushion Morphogenesis Atrioventricular Valve Development Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Cardiac Epithelial To Mesenchymal Transition Telomere Maintenance Via Recombination Amine Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Heart Morphogenesis Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Epithelial To Mesenchymal Transition Polyamine Metabolic Process Heart Valve Morphogenesis DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Heart Valve Development Endocardial Cushion Development Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transcription-coupled Nucleotide-excision Repair Embryonic Axis Specification	Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Myoblast Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Telomere Maintenance Via Telomere Shortening Positive Regulation Of G0 To G1 Transition Regulation Of Cell Cycle Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Myoblast Proliferation Regulation Of Myoblast Proliferation Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Chromatin Organization Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Cell Cycle Regulation Of Telomere Maintenance RNA-dependent DNA Replication Chromosome Organization Negative Regulation Of DNA Biosynthetic Process Skeletal Muscle Tissue Regeneration Regulation Of Microtubule Polymerization Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Myoblast Differentiation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Wound Healing Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Muscle Organ Development Tissue Regeneration Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			0mg 1cm 3ml 4cm 73m2 82ml annual categorize charlson choose ckd comorbidity definitive exceeded expect experienced formula fourth initiative institutional interventional masses minimally registry scr surveillance thirds upstaging yearly
Tagcloud (Difference) ?			0mg 1cm 3ml 4cm 73m2 82ml annual categorize charlson choose ckd comorbidity definitive exceeded expect experienced formula fourth initiative institutional interventional masses minimally registry scr surveillance thirds upstaging yearly
Tagcloud (Intersection) ?