POLA1 and KLHL15

		POLA1	KLHL15
Description		DNA polymerase alpha 1, catalytic subunit	kelch like family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Cytosol Nuclear Matrix	Nucleus Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Protein Kinase Binding DNA Polymerase Activity Metal Ion Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Prostate-specific antigen levels ( 28139693)
Interacting Genes		18 interacting genes: CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	3 interacting genes: MARCHF6-DT PPP2R2B RBBP8
Entrez ID		5422	80311
HPRD ID		02416	09957
Ensembl ID		ENSG00000101868	ENSG00000174010
Uniprot IDs		A6NMQ1 P09884	Q96M94 V9HWF1
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7 7N2M 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V 9MJ5
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication DNA Repair Nucleic Acid Metabolic Process DNA-templated DNA Replication DNA Damage Response Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromosome Organization DNA Replication, Synthesis Of Primer Macromolecule Metabolic Process Chromosome, Telomeric Region Chromatin Binding Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleoplasm Double-strand Break Repair Regulation Of Chromosome Organization Response To Gamma Radiation Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process Recombinational Repair Chromosome Cellular Response To Radiation DNA Binding G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Activity DNA Replication Proofreading DNA Biosynthetic Process DNA Replication Initiation Cellular Response To Gamma Radiation Site Of Double-strand Break Telomere Maintenance Nucleus Negative Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome PML Body DNA Recombination Alpha DNA Polymerase:primase Complex Glial Cell Apoptotic Process Response To Radiation Regulation Of Cell Cycle Phase Transition Telomere Organization Histone Kinase Activity Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Cell Cycle Process 4 Iron, 4 Sulfur Cluster Binding Double-strand Break Repair Via Homologous Recombination	Double-strand Break Repair Mitotic DNA Replication Initiation Lagging Strand Elongation Alpha DNA Polymerase:primase Complex DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation DNA Replication, Synthesis Of Primer BRCA1-C Complex DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Poly-ADP-D-ribose Binding Regulation Of Protein ADP-ribosylation Single-stranded DNA Endodeoxyribonuclease Activity DNA Strand Elongation Involved In DNA Replication DNA Polymerase Activity DNA Replication Origin Binding Protein Phosphatase Type 2A Complex DNA Strand Resection Involved In Replication Fork Processing DNA Strand Elongation DNA Repair DNA-directed DNA Polymerase Activity DNA Replication Initiation Blastocyst Hatching DNA Double-strand Break Processing
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