GJB5 and PCGF2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GJB5	PCGF2
Gene Name		gap junction protein, beta 5, 31.1kDa	polycomb group ring finger 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Connexon Complex Integral Component Of Membrane	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function		DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Cell Communication Epidermis Development Spongiotrophoblast Differentiation Labyrinthine Layer Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Anterior/posterior Pattern Specification Protein Ubiquitination Histone Acetylation Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		5 interactors: GSK3B MED1 MYL2 PCGF2 TRIM2	23 interactors: ABHD6 CBX6 CBX7 CBX8 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		2709	7703
HPRD ID		06840	10621
Ensembl ID		ENSG00000189280	ENSG00000056661
Uniprot IDs		O95377	P35227
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Regulation Of Apoptotic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Regulation Of Cell Death Cardiac Ventricle Morphogenesis Muscle Structure Development Cardiac Ventricle Development Positive Regulation Of Nucleocytoplasmic Transport Thyroid Hormone Mediated Signaling Pathway Muscle Cell Fate Specification Fat Cell Differentiation Regulation Of Epithelial Cell Differentiation Cardiac Chamber Development Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Cardiac Muscle Tissue Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Cell Death Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Hypermethylation Of CpG Island Positive Regulation Of G0 To G1 Transition Enucleate Erythrocyte Development Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Anatomical Structure Formation Involved In Morphogenesis Heart Morphogenesis Striated Muscle Cell Differentiation Depyrimidination Cellular Response To Interleukin-3 Positive Regulation Of Intracellular Transport Organ Development Regulation Of Vitamin D Receptor Signaling Pathway Mammary Gland Branching Involved In Thelarche Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Hepatocyte Proliferation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation	Histone Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Chromatin Modification Chromatin Organization Protein Polyubiquitination Histone Modification Chromosome Organization Protein K48-linked Ubiquitination Protein Monoubiquitination Histone H2A Monoubiquitination Cellular Protein Modification Process Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Histone Monoubiquitination Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Sterol Regulatory Element Binding Protein Import Into Nucleus RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Anterior/posterior Pattern Specification Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Catabolic Process Regulation Of Gene Expression Protein Linear Polyubiquitination Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Tagcloud ?		5and ascl2 compete connexins ctsq cx cx31 delaying derivation disparate e10 e13 gjb3 id2 junctional manifested opposed opposition pl placental placentas placentation prl3b1 spaces stereology subpopulations tgc tpbpa trophoblast	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?		5and ascl2 compete connexins ctsq cx cx31 delaying derivation disparate e10 e13 gjb3 id2 junctional manifested opposed opposition pl placental placentas placentation prl3b1 spaces stereology tgc tpbpa trophoblast	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 trithorax
Tagcloud (Intersection) ?		subpopulations