GJB5 and TMEM86A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB5	TMEM86A
Description		gap junction protein beta 5	transmembrane protein 86A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Protein Binding Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
	Biological Process	Cell Communication Cell-cell Signaling Epidermis Development Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Morphogenesis	Lipid Metabolic Process
Pathways		Gap junction assembly
Drugs
Diseases
GWAS		BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Narcolepsy ( 23459209) Sleep duration (short sleep) ( 30846698) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Visceral adipose tissue adjusted for BMI ( 22589738)	Ovarian reserve ( 22116950)
Interacting Genes		44 interacting genes: APOL2 APOL3 AQP1 ARLN C1GALT1 COMT CTXN3 CYB5B ERG28 FAM3C GSK3B IGFBP5 JAGN1 LMNA LPAR3 LRP10 MED1 MIP MS4A13 MYL2 NAPB PCGF2 PGAP2 PLPP4 PLPP6 PNLIPRP1 RPRM RTP2 SEC22A SEC22B SERP1 SLC30A2 SLC38A7 SLC41A1 SLC41A2 SMIM1 TM4SF4 TMEM128 TMEM60 TMEM86A TMEM97 TRIM2 TSPO2 VSTM1	48 interacting genes: AQP2 AQP3 BCL2L13 CD79A CISD2 CNR2 COQ9 CPLX4 CREB3L1 EBP ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 FXYD3 GJB4 GJB5 GJC1 GORAB GPR37L1 GPX8 HAVCR2 KASH5 KCNA1 LHFPL5 LMNA MS4A2 MUC1 NCAPH2 PDZK1IP1 PGRMC2 PI16 REEP4 RIC3 RNF185 SCN3B SLC10A6 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SSMEM1 THAP4 TIMMDC1 TMEM31 TMPRSS2 TYROBP
Entrez ID		2709	144110
HPRD ID		06840	08292
Ensembl ID		ENSG00000189280	ENSG00000151117
Uniprot IDs		A0A654IE64 O95377	Q8N2M4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Monoatomic Cation Transmembrane Transporter Activity Endoplasmic Reticulum Membrane Protein Binding Neutrophil Differentiation Inorganic Cation Transmembrane Transporter Activity	Membrane Transmembrane Transport Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Glycerol Transmembrane Transport Monoatomic Ion Transport Renal Water Transport Endoplasmic Reticulum Polyol Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Transport Vesicle Membrane
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