MYO3A and POLR2M

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYO3A	POLR2M
Gene Name		myosin IIIA	polymerase (RNA) II (DNA directed) polypeptide M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Myosin Complex Filopodium Filamentous Actin Stereocilium Bundle Tip Filopodium Tip	Nuclear Envelope DNA-directed RNA Polymerase II, Holoenzyme Neuronal Cell Body
	Molecular Function	Microfilament Motor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Plus-end Directed Microfilament Motor Activity	DNA-directed RNA Polymerase Activity
	Biological Process	Visual Perception Sensory Perception Of Sound Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Protein Autophosphorylation Inner Ear Development Response To Stimulus Positive Regulation Of Filopodium Assembly	RNA Biosynthetic Process Maintenance Of ER Location
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) PR interval ( 23534349)
Protein-Protein Interactions		2 interactors: POLR2M TGFBR1	19 interactors: AHSP ANKHD1 APOD CEBPG DGKZ HIGD1B KIAA1377 MYO3A MYO9A NEDD4 PSMC2 RBM4B RPL7A SCMH1 SIVA1 THAP1 UQCRQ WDR89 ZNF410
Entrez ID		53904	81488
HPRD ID		06008	07575
Ensembl ID		ENSG00000095777	ENSG00000255529
Uniprot IDs		Q8NEV4	P0CAP1 P0CAP2 Q6EEV4
PDB IDs			2KXS
Enriched GO Terms of Interacting Partners?		Maintenance Of ER Location Endoplasmic Reticulum Localization Parathyroid Gland Development Endothelial Cell Activation Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Germ Cell Migration Pharyngeal System Development Response To Cholesterol Negative Regulation Of Chondrocyte Differentiation Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cartilage Development Positive Regulation Of Filopodium Assembly	Viral Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Transmission Of Virus Development Involved In Symbiotic Interaction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Subthalamus Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Lipoprotein Lipid Oxidation Mitotic DNA Damage Checkpoint Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Interaction With Host Regulation Of Mitotic Cell Cycle Negative Regulation Of Lymphocyte Migration Regulation Of Intracellular Transport Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Progesterone Receptor Signaling Pathway Developmental Process
Tagcloud ?		amplified antagonism antagonizers dimerization distinguish driving exerted her2 her3 heterodimer heterodimers homodimers intended kinome layers mitogenic mpzl1 myo3b pinpoint potentiated screen screens sensitization sensitize si sirna trastuzumab unaffected vesicle
Tagcloud (Difference) ?		amplified antagonism antagonizers dimerization distinguish driving exerted her2 her3 heterodimer heterodimers homodimers intended kinome layers mitogenic mpzl1 myo3b pinpoint potentiated screen screens sensitization sensitize si sirna trastuzumab unaffected vesicle
Tagcloud (Intersection) ?