LIPE and FABP4

Number of citations of the paper that reports this interaction (PubMedID 10318917)
36

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo, in vitro, two hybrid)

		LIPE	FABP4
Description		lipase E, hormone sensitive type	fatty acid binding protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Caveola Membrane	Nucleus Cytoplasm Lipid Droplet Cytosol Extracellular Exosome
	Molecular Function	Sterol Ester Esterase Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Monoacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Retinyl-palmitate Esterase Activity Diacylglycerol Lipase Activity	Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Binding Lipid Binding Long-chain Fatty Acid Binding Hormone Receptor Binding
	Biological Process	Protein Phosphorylation Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Retinol Metabolic Process Diacylglycerol Catabolic Process Ether Lipid Metabolic Process	Response To Bacterium Fatty Acid Transport Long-chain Fatty Acid Transport Cholesterol Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response White Fat Cell Differentiation Brown Fat Cell Differentiation Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cold-induced Thermogenesis
Pathways		Triglyceride catabolism MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Triglyceride catabolism Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Metabolite levels ( 23823483) Ovarian cancer ( 23535730) Visceral fat ( 22589738)
Interacting Genes		11 interacting genes: FABP4 KATNA1 MAPK1 MAPK3 MTNR1A NSFL1C PLIN1 PLIN5 PRKACA STAR TSGA10IP	9 interacting genes: ACP1 ACTB CHD3 INSR LIPE PRKCI TNFAIP3 VIM ZBED1
Entrez ID		3991	2167
HPRD ID		01062	02698
Ensembl ID		ENSG00000079435	ENSG00000170323
Uniprot IDs		A8K8W7 Q05469	E7DVW4 P15090
PDB IDs			1TOU 1TOW 2HNX 2NNQ 3FR2 3FR4 3FR5 3P6C 3P6D 3P6E 3P6F 3P6G 3P6H 3Q6L 3RZY 4NNS 4NNT 5D45 5D47 5D48 5D4A 5EDB 5EDC 5HZ6 5HZ8 5Y0F 5Y0G 5Y0X 5Y12 5Y13 6AYL 6LJS 6LJT 6LJU 6LJV 6LJW 6LJX 7FVU 7FVV 7FVW 7FVX 7FVY 7FVZ 7FW0 7FW1 7FW2 7FW3 7FW4 7FW5 7FW6 7FW7 7FW8 7FW9 7FWA 7FWB 7FWC 7FWD 7FWE 7FWF 7FWG 7FWH 7FWJ 7FWK 7FWL 7FWM 7FWN 7FWO 7FWP 7FWQ 7FWR 7FWS 7FWU 7FWV 7FWW 7FWX 7FWY 7FWZ 7FX0 7FX1 7FX2 7FX3 7FX4 7FX5 7FX6 7FX7 7FX8 7FX9 7FXA 7FXB 7FXC 7FXE 7FXF 7FXG 7FXH 7FXI 7FXJ 7FXK 7FXL 7FXM 7FXN 7FXP 7FXQ 7FXR 7FXS 7FXT 7FXU 7FXV 7FXW 7FXX 7FXY 7FXZ 7FY2 7FY3 7FY4 7FY5 7FY6 7FY7 7FY9 7FYB 7FYC 7FYE 7FYF 7FYG 7FYH 7FYI 7FYJ 7FYK 7FYL 7FYM 7FYO 7FYP 7FYQ 7FYR 7FYS 7FYT 7FYU 7FYV 7FYX 7FYY 7FYZ 7FZ0 7FZ1 7FZ2 7FZ3 7FZ4 7FZ5 7FZ6 7FZ7 7FZ8 7FZ9 7FZA 7FZB 7FZC 7FZD 7FZE 7FZF 7FZH 7FZI 7FZJ 7FZK 7FZL 7FZM 7FZN 7FZO 7FZP 7FZR 7FZS 7FZT 7FZU 7FZV 7FZW 7FZX 7FZY 7FZZ 7G02 7G03 7G05 7G06 7G07 7G08 7G09 7G0A 7G0C 7G0F 7G0G 7G0H 7G0I 7G0J 7G0K 7G0L 7G0M 7G0N 7G0O 7G0P 7G0Q 7G0R 7G0S 7G0T 7G0U 7G0V 7G0X 7G0Y 7G0Z 7G10 7G11 7G12 7G13 7G14 7G15 7G16 7G17 7G18 7G19 7G1A 7G1B 7G1C 7G1D 7G1E 7G1F 7G1G 7G1H 7G1I 7G1J 7G1K 7G1L 7G1M 7G1N 7G1O 7G1P 7G1R 7G1S 7G1T 7G1U 7G1V 7G1W 7G1Y 7G1Z 7G20 7G21 7WC3 8S1K 8WDX 8WE3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Regulation Of Golgi Inheritance Interleukin-34-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Lipid Biosynthetic Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Steroid Biosynthetic Process Bergmann Glial Cell Differentiation Lipid Droplet Cellular Response To Tumor Necrosis Factor Cellular Response To Cold Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Lipid Binding MAP Kinase Activity Regulation Of Golgi Organization Pseudopodium Response To Tumor Necrosis Factor Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cholesterol Biosynthetic Process Face Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration Neural Crest Cell Development Lung Morphogenesis Positive Regulation Of Inflammatory Response Positive Regulation Of Cholesterol Metabolic Process Regulation Of Macrophage Chemotaxis Thyroid Gland Development Regulation Of Cholesterol Biosynthetic Process Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Stem Cell Development Regulation Of Stress-activated MAPK Cascade	Cytoskeleton Organization Cellular Response To Oxygen-containing Compound Response To Muramyl Dipeptide Extracellular Exosome Tight Junction Positive Regulation Of D-glucose Import Brush Border Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Cell Leading Edge Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Protein Autosumoylation Hydrolase Activity Protein Modification Process Protein Phosphorylation Caveola Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Cell Population Proliferation Phosphorylation Axon Regulation Of Norepinephrine Uptake Identical Protein Binding Diacylglycerol Lipase Activity Negative Regulation Of CD40 Signaling Pathway Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Cellular Response To Insulin Stimulus Transporter Regulator Activity PML Body PTB Domain Binding Insulin Receptor Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Plasma Membrane Regulation Of Transepithelial Transport Nuclear Matrix Insulin Receptor Complex Sterol Ester Esterase Activity Golgi Vesicle Budding Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B-1 B Cell Homeostasis
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