LIPE and PLIN5

Number of citations of the paper that reports this interaction (PubMedID 19717842)
46

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		LIPE	PLIN5
Description		lipase E, hormone sensitive type	perilipin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Caveola Membrane	Cytoplasm Mitochondrion Lipid Droplet Cytosol
	Molecular Function	Sterol Ester Esterase Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Monoacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Retinyl-palmitate Esterase Activity Diacylglycerol Lipase Activity	Protein Binding Lipase Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Retinol Metabolic Process Diacylglycerol Catabolic Process Ether Lipid Metabolic Process	Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Positive Regulation Of Triglyceride Storage Negative Regulation Of Triglyceride Catabolic Process Lipid Storage Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Lipid Droplet Organization Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Lipid Catabolic Process Mitochondrion Localization Negative Regulation Of Lipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Triglyceride catabolism MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS
Interacting Genes		11 interacting genes: FABP4 KATNA1 MAPK1 MAPK3 MTNR1A NSFL1C PLIN1 PLIN5 PRKACA STAR TSGA10IP	1 interacting genes: LIPE
Entrez ID		3991	440503
HPRD ID		01062	18450
Ensembl ID		ENSG00000079435	ENSG00000214456
Uniprot IDs		A8K8W7 Q05469	Q00G26
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Regulation Of Golgi Inheritance Interleukin-34-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Lipid Biosynthetic Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Steroid Biosynthetic Process Bergmann Glial Cell Differentiation Lipid Droplet Cellular Response To Tumor Necrosis Factor Cellular Response To Cold Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Lipid Binding MAP Kinase Activity Regulation Of Golgi Organization Pseudopodium Response To Tumor Necrosis Factor Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cholesterol Biosynthetic Process Face Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration Neural Crest Cell Development Lung Morphogenesis Positive Regulation Of Inflammatory Response Positive Regulation Of Cholesterol Metabolic Process Regulation Of Macrophage Chemotaxis Thyroid Gland Development Regulation Of Cholesterol Biosynthetic Process Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Stem Cell Development Regulation Of Stress-activated MAPK Cascade	Sterol Ester Esterase Activity Diacylglycerol Lipase Activity Retinyl-palmitate Esterase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Diacylglycerol Catabolic Process Monoacylglycerol Lipase Activity Lipase Activity Ether Lipid Metabolic Process Diacylglycerol Metabolic Process Triglyceride Catabolic Process Triacylglycerol Lipase Activity Acylglycerol Catabolic Process Retinol Metabolic Process Triglyceride Metabolic Process Diterpenoid Metabolic Process Retinoid Metabolic Process Terpenoid Metabolic Process Lipid Droplet Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Caveola Isoprenoid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Olefinic Compound Metabolic Process Hormone Metabolic Process Steroid Metabolic Process Lipid Catabolic Process Alcohol Metabolic Process Glycerolipid Metabolic Process Protein Phosphorylation Phosphorylation Regulation Of Hormone Levels
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