ATP6V1G2 and USP20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V1G2	USP20
Description		ATPase H+ transporting V1 subunit G2	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytosol Membrane Vacuolar Proton-transporting V-type ATPase Complex Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Melanosome Extrinsic Component Of Synaptic Vesicle Membrane	Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Regulation Of Macroautophagy Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Proteolysis Endocytosis Canonical NF-kappaB Signal Transduction Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Ub-specific processing proteases
Drugs		Tiludronic acid
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) LDL cholesterol levels ( 32203549) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Myositis ( 26291516) Ulcerative colitis ( 28067908)	Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: ATP6V1E1 ATP6V1E2 USP20	71 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GPRASP3 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPAST SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB
Entrez ID		534	10868
HPRD ID		06030	07505
Ensembl ID		ENSG00000213760	ENSG00000136878
Uniprot IDs		O95670 Q6NVJ2	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?		Proton-transporting Two-sector ATPase Complex, Catalytic Domain Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of Autophagy Proton Transmembrane Transport Regulation Of Macroautophagy Proton-transporting Two-sector ATPase Complex Vacuolar Proton-transporting V-type ATPase, V1 Domain Inorganic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Synaptic Vesicle Lumen Acidification Inorganic Cation Transmembrane Transport Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Clathrin-coated Vesicle Membrane	Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Stress FFAT Motif Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleus COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Hemoglobin Biosynthetic Process Ubiquitin Protein Ligase Binding Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Localization Vesicle Budding From Membrane Cellular Response To Oxygen Levels Protein Kinase Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Oxygen Homeostasis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Mitotic DNA Replication Checkpoint Signaling Alpha-tubulin Binding Host-mediated Activation Of Viral Genome Replication Hemoglobin Metabolic Process Peripheral Nervous System Neuron Development Negative Regulation Of Apoptotic Process Regulation Of Skeletal Muscle Adaptation Host-mediated Perturbation Of Viral Genome Replication Neuroblast Proliferation Negative Regulation Of Programmed Cell Death
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