ATP6V1G2

Description		ATPase H+ transporting V1 subunit G2
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytosol Membrane Vacuolar Proton-transporting V-type ATPase Complex Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Melanosome Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Monoatomic Ion Transport Regulation Of Macroautophagy Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) LDL cholesterol levels ( 32203549) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Myositis ( 26291516) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: ATP6V1E1 ATP6V1E2 USP20
Entrez ID		534
HPRD ID		06030
Ensembl ID		ENSG00000213760
Uniprot IDs		O95670 Q6NVJ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Proton-transporting Two-sector ATPase Complex, Catalytic Domain Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of Autophagy Proton Transmembrane Transport Regulation Of Macroautophagy Proton-transporting Two-sector ATPase Complex Vacuolar Proton-transporting V-type ATPase, V1 Domain Inorganic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Synaptic Vesicle Lumen Acidification Inorganic Cation Transmembrane Transport Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Clathrin-coated Vesicle Membrane
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