PKN3 and ARHGAP26

Number of citations of the paper that reports this interaction (PubMedID 11432776)
0

Data Source:
HPRD (two hybrid, in vivo)

		PKN3	ARHGAP26
Description		protein kinase N3	Rho GTPase activating protein 26
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Endosome Cytosol Cytoskeleton Focal Adhesion Endosome Membrane Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Protein Serine Kinase Activity	GTPase Activator Activity Protein Binding Phospholipid Binding Protein-macromolecule Adaptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Intracellular Signal Transduction	Mitophagy Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Asthma ( 31361310) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457) Gamma glutamyl transferase levels ( 29403010 33339817) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Pulse pressure ( 27841878) Septic shock resolution ( 32755526) Suicide attempt severity in mood disorders ( 33783297) Waist circumference ( 28552196)
Interacting Genes		9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52	8 interacting genes: CDC42 CDC42EP2 INSR PKN1 PKN3 PTK2 RHOA SRPK1
Entrez ID		29941	23092
HPRD ID		17856	05643
Ensembl ID		ENSG00000160447	ENSG00000145819
Uniprot IDs		Q6P5Z2	A0A0S2Z536 A0A2R8YGB3 Q9UNA1
PDB IDs			1UGV
Enriched GO Terms of Interacting Partners?		Syntaxin Binding Endosome Embryonic Ectodermal Digestive Tract Development Endosome Membrane	Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Kinase Activity Kinase Activity Establishment Of Cell Polarity Positive Regulation Of Pseudopodium Assembly ATP Binding Phosphate-containing Compound Metabolic Process Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Ameboidal-type Cell Migration Cell Migration Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Locomotion Positive Regulation Of Organelle Organization Polarized Epithelial Cell Differentiation Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Midbody Signal Transduction Cell Motility Positive Regulation Of Cell Migration Dendritic Spine Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cell Motility Plasma Membrane Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Positive Regulation Of Locomotion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cytokinesis Neuron Projection Organization Substantia Nigra Development Postsynapse Organization Membrane Invagination Actin Filament Organization Positive Regulation Of Cell Cycle Process Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway
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