ATP6V1A and RALGAPA1

		ATP6V1A	RALGAPA1
Description		ATPase H+ transporting V1 subunit A	Ral GTPase activating protein catalytic subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Microvillus Endosome Membrane Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism	GTPase Activator Activity Protein Heterodimerization Activity
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Homeostatic Process ATP Metabolic Process Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	RHOH GTPase cycle
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Prostate cancer ( 23535732)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte count ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ANXA7 CDC42 CDKN1A SMN1 TK1 TUFM UBC	2 interacting genes: ERBB3 TCF3
Entrez ID		523	253959
HPRD ID		06120	12324
Ensembl ID		ENSG00000114573	ENSG00000174373
Uniprot IDs		P38606	A0A1B0GUI1 A0A7P0TAR5 H0YJB5 Q6GYQ0
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?			Nucleotide Binding ATPase Complex Proton-transporting V-type ATPase, V1 Domain Apical Plasma Membrane Extrinsic Component Of Synaptic Vesicle Membrane Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Endosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Negative Regulation Of Motor Neuron Apoptotic Process Neuregulin Receptor Activity Motor Neuron Apoptotic Process ERBB2-ERBB3 Signaling Pathway Schwann Cell Differentiation ERBB3 Signaling Pathway Protein Tyrosine Kinase Activator Activity Neuregulin Binding Endocardial Cushion Development Regulation Of Cardiac Muscle Tissue Development Protein Heterodimerization Activity Leukocyte Differentiation Signal Recognition Particle Cotranslational Protein Targeting To Membrane Exocrine Pancreas Development Endoplasmic Reticulum Signal Peptide Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation 7S RNA Binding SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition SRP-dependent Cotranslational Protein Targeting To Membrane Vitamin D Response Element Binding B Cell Lineage Commitment Immunoglobulin V(D)J Recombination Mitogen-activated Protein Kinase Kinase Kinase Binding Synaptic Vesicle Lumen Acidification Proton-transporting V-type ATPase Complex Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade V(D)J Recombination Positive Regulation Of Striated Muscle Tissue Development ERBB2 Signaling Pathway Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Peripheral Nervous System Development Granulocyte Differentiation
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