ATP6V1A and TMPRSS7

		ATP6V1A	TMPRSS7
Description		ATPase H+ transporting V1 subunit A	transmembrane serine protease 7
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Microvillus Endosome Membrane Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Homeostatic Process ATP Metabolic Process Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Proteolysis
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Prostate cancer ( 23535732)	Telomere length ( 24478790)
Interacting Genes		7 interacting genes: ANXA7 CDC42 CDKN1A SMN1 TK1 TUFM UBC
Entrez ID		523	344805
HPRD ID		06120	19178
Ensembl ID		ENSG00000114573	ENSG00000176040
Uniprot IDs		P38606	Q7RTY8
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?			ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extrinsic Component Of Synaptic Vesicle Membrane Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Endosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Synaptic Vesicle Lumen Acidification Proton-transporting V-type ATPase Complex Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Regulation Of Lysosomal Lumen PH Clathrin-coated Vesicle Membrane Vacuolar Acidification Intracellular PH Reduction Intracellular Iron Ion Homeostasis Microvillus Neuron Cellular Homeostasis Regulation Of Cellular PH Regulation Of Intracellular PH Transport Vesicle Regulation Of PH Secretory Granule Cellular Response To Oxygen Levels ATP Metabolic Process Proton Transmembrane Transport Regulation Of Macroautophagy Purine Ribonucleotide Metabolic Process Endosome Membrane Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process
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