ATP6V1A and CD200R1L

		ATP6V1A	CD200R1L
Description		ATPase H+ transporting V1 subunit A	CD200 receptor 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Microvillus Endosome Membrane Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex	External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Signaling Receptor Activity
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Homeostatic Process ATP Metabolic Process Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Regulation Of Neuroinflammatory Response
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Prostate cancer ( 23535732)	High density lipoprotein cholesterol levels ( 34074324)
Interacting Genes		7 interacting genes: ANXA7 CDC42 CDKN1A SMN1 TK1 TUFM UBC	1 interacting genes: NKX3-1
Entrez ID		523	344807
HPRD ID		06120	16691
Ensembl ID		ENSG00000114573	ENSG00000206531
Uniprot IDs		P38606	Q6Q8B3
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?			Cellular Response To Oxygen Levels Positive Regulation Of Androgen Secretion MADS Box Domain Binding Dorsal Aorta Development Response To Oxygen Levels Salivary Gland Development Proton-transporting Two-sector ATPase Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extrinsic Component Of Synaptic Vesicle Membrane Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Endosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Branching Involved In Prostate Gland Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Proton-transporting V-type ATPase Complex Urogenital System Development Prostate Gland Development Synaptic Vesicle Lumen Acidification Pharyngeal System Development Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Prostate Gland Epithelium Morphogenesis Androgen Receptor Signaling Pathway Regulation Of Lysosomal Lumen PH Aorta Development Clathrin-coated Vesicle Membrane Vacuolar Acidification Metanephros Development Nuclear Estrogen Receptor Binding Transcription Regulator Inhibitor Activity Response To Testosterone Site Of DNA Damage Artery Development Somitogenesis Intracellular PH Reduction Cellular Response To Interleukin-1 Segmentation Nuclear Receptor Activity Neuron Cellular Homeostasis Intracellular Iron Ion Homeostasis Microvillus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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