GBE1 and PGD

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		GBE1	PGD
Description		1,4-alpha-glucan branching enzyme 1	phosphogluconate dehydrogenase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity 1,4-alpha-glucan Branching Enzyme Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Cation Binding	Phosphogluconate Dehydrogenase (decarboxylating) Activity Oxidoreductase Activity Carbohydrate Binding Carboxylic Acid Binding NADP Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Generation Of Precursor Metabolites And Energy Negative Regulation Of Neuron Apoptotic Process	Pentose-phosphate Shunt NADP+ Metabolic Process NADPH Regeneration Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process
Pathways		Glycogen synthesis Glycogen storage disease type IV (GBE1)	Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs			Gadopentetic acid Dacarbazine Ketotifen 6-phospho-D-gluconic acid Nicotinamide 8-bromo-adenine dinucleotide phosphate
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cadmium levels ( 26025379) Chronotype ( 30696823) Daytime nap ( 33568662) Extraversion ( 27918536) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29691431) Intraocular pressure ( 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Lead levels in blood ( 25820613) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Meat-related diet ( 32066663) Photic sneeze reflex ( 30899065) Processed meat consumption ( 32066663) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference ( 25673412)	Hemoglobin ( 32888494) Hepatocellular carcinoma ( 20676096) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: CEBPA EPHB3 KLHL20 PGD PRMT6 RIPK3 TRDMT1 UBC	8 interacting genes: CDC42 CDK4 GBE1 LINC00632 LINC01554 LSM8 OGT TERF1
Entrez ID		2632	5226
HPRD ID		01985	01391
Ensembl ID		ENSG00000114480	ENSG00000142657
Uniprot IDs		Q04446 Q59ET0	B4E2U0 P52209
PDB IDs		4BZY 5CLT 5CLW	2JKV 4GWG 4GWK 5UQ9
Enriched GO Terms of Interacting Partners?		Gland Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Hematopoietic Or Lymphoid Organ Development Thymus Development Pentose Biosynthetic Process D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Cortical Microtubule Plus-end Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Protein K33-linked Ubiquitination Type II Interferon Binding Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity CHOP-C/EBP Complex TRNA (cytidine-5-)-methyltransferase Activity Execution Phase Of Necroptosis Histone Arginine N-methyltransferase Activity	Glycosyltransferase Activity 1,4-alpha-glucan Branching Enzyme Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glycosylation-dependent Protein Binding Dolichyl-phosphate Beta-glucosyltransferase Activity GBD Domain Binding Storage Vacuole Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
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