GBE1 and TRDMT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GBE1	TRDMT1
Description		1,4-alpha-glucan branching enzyme 1	tRNA aspartic acid methyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Catalytic Activity 1,4-alpha-glucan Branching Enzyme Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Cation Binding	RNA Binding Methyltransferase Activity TRNA Methyltransferase Activity TRNA (cytidine-5-)-methyltransferase Activity Transferase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Generation Of Precursor Metabolites And Energy Negative Regulation Of Neuron Apoptotic Process	TRNA Modification TRNA Processing TRNA Methylation Methylation TRNA Stabilization
Pathways		Glycogen synthesis Glycogen storage disease type IV (GBE1)	tRNA modification in the nucleus and cytosol
Drugs			Pentamidine S-adenosyl-L-homocysteine Glycerin
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cadmium levels ( 26025379) Chronotype ( 30696823) Daytime nap ( 33568662) Extraversion ( 27918536) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29691431) Intraocular pressure ( 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Lead levels in blood ( 25820613) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Meat-related diet ( 32066663) Photic sneeze reflex ( 30899065) Processed meat consumption ( 32066663) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference ( 25673412)	Aspartate aminotransferase levels ( 33547301) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Telomere length ( 24478790)
Interacting Genes		8 interacting genes: CEBPA EPHB3 KLHL20 PGD PRMT6 RIPK3 TRDMT1 UBC	14 interacting genes: APP COPS6 DDX24 EEF1A1 GBE1 LRIF1 NFRKB RBM48 SETDB1 SNRPD3 STX1A TBC1D2B UNC119 UTP14A
Entrez ID		2632	1787
HPRD ID		01985	16001
Ensembl ID		ENSG00000114480	ENSG00000107614
Uniprot IDs		Q04446 Q59ET0	B4DQZ2 O14717 Q6ICS7 Q7Z3E4
PDB IDs		4BZY 5CLT 5CLW	1G55
Enriched GO Terms of Interacting Partners?		Gland Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Hematopoietic Or Lymphoid Organ Development Thymus Development Pentose Biosynthetic Process D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Cortical Microtubule Plus-end Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Protein K33-linked Ubiquitination Type II Interferon Binding Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity CHOP-C/EBP Complex TRNA (cytidine-5-)-methyltransferase Activity Execution Phase Of Necroptosis Histone Arginine N-methyltransferase Activity
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