PGAM2 and CLVS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGAM2	CLVS2
Description		phosphoglycerate mutase 2	clavesin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Endosome Golgi Apparatus Trans-Golgi Network Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane
	Molecular Function	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity Identical Protein Binding	Protein Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Gluconeogenesis Glycolytic Process Striated Muscle Contraction Notch Signaling Pathway Spermatogenesis Response To Mercury Ion Canonical Glycolysis	Lysosome Organization
Pathways		Glycolysis Gluconeogenesis	Lysosome Vesicle Biogenesis
Drugs		Benzene Hexacarboxylic Acid 3-phospho-D-glyceric acid
Diseases
GWAS			Refractive error ( 32231278) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		4 interacting genes: CLVS2 DYNC1LI1 KATNAL1 MDM2	16 interacting genes: EMSY FBXW2 FLAD1 GSTM3 GSTZ1 GYS1 KAZN MEOX2 MYH7 PAFAH1B2 PCYT2 PGAM2 PHETA2 S100A7 S100A7A TACC2
Entrez ID		5224	134829
HPRD ID		02027	16666
Ensembl ID		ENSG00000164708	ENSG00000146352
Uniprot IDs		P15259	Q5SYC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Membrane Response To Formaldehyde Cellular Response To Vitamin B1 Response To Vitamin B1 NEDD8 Ligase Activity Response To Actinomycin D Positive Regulation Of Cell Cycle Process Receptor Serine/threonine Kinase Binding Response To Water-immersion Restraint Stress Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Actinomycin D Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Spindle Pole Early Endosome To Recycling Endosome Transport Katanin Complex Microtubule Severing ATPase Activity Regulation Of Mitotic Cell Cycle Phase Transition Atrial Septum Development Fibroblast Activation Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic Positive Regulation Of Cell Cycle 5S RRNA Binding Microtubule Microtubule Severing Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Phosphatidylinositol Bisphosphate Binding SUMO Transferase Activity Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Estrogen Stimulus Endocardial Cushion Morphogenesis Regulation Of Cell Cycle Phase Transition Response To Ether Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Magnesium Ion Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Protein Export From Nucleus Regulation Of Vesicle-mediated Transport Response To Immobilization Stress Heart Valve Development Regulation Of Mitotic Cell Cycle Atrioventricular Valve Morphogenesis Response To UV-C Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Supramolecular Fiber Organization Cytoplasmic Dynein Complex Microtubule Cytoskeleton Organization	Catalytic Activity Transition Metal Ion Binding Glutathione Transferase Activity Identical Protein Binding Cytosol Maleylacetoacetate Isomerase Activity Ethanolamine-phosphate Cytidylyltransferase Activity FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity
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