PGAM2 and DYNC1LI1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PGAM2	DYNC1LI1
Name		phosphoglycerate mutase 2	dynein cytoplasmic 1 light intermediate chain 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Dynein Complex Endocytic Vesicle Membrane Secretory Granule Membrane Recycling Endosome Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity Identical Protein Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Protein-macromolecule Adaptor Activity Dynein Heavy Chain Binding Molecular Adaptor Activity
	Biological Process	Gluconeogenesis Glycolytic Process Striated Muscle Contraction Notch Signaling Pathway Spermatogenesis Response To Mercury Ion Canonical Glycolysis	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Glycolysis Gluconeogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Benzene Hexacarboxylic Acid 3-phospho-D-glyceric acid	None
GWAS		No GWAS studies recorded	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Low density lipoprotein cholesterol levels ( 33339817 )
Interacting Genes		4 interacting genes: CLVS2 DYNC1LI1 KATNAL1 MDM2	11 interacting genes: BRCA2 CEBPA IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL RUFY1 SLC25A21-AS1
Entrez ID		5224	51143
HPRD ID		02027	10917
Ensembl ID		ENSG00000164708	ENSG00000144635
Uniprot IDs		P15259	B3KM42 E9PHI6 Q9Y6G9
PDB IDs		Not available	6B9H 6PSD 6PSE
GO Terms Enriched among Interactors		Endocytic Vesicle Membrane Response To Formaldehyde Cellular Response To Vitamin B1 Response To Vitamin B1 NEDD8 Ligase Activity Response To Actinomycin D Positive Regulation Of Cell Cycle Process Receptor Serine/threonine Kinase Binding Response To Water-immersion Restraint Stress Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Actinomycin D Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Spindle Pole Early Endosome To Recycling Endosome Transport Katanin Complex Microtubule Severing ATPase Activity Regulation Of Mitotic Cell Cycle Phase Transition Atrial Septum Development Fibroblast Activation Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic Positive Regulation Of Cell Cycle 5S RRNA Binding Microtubule Microtubule Severing Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Phosphatidylinositol Bisphosphate Binding SUMO Transferase Activity Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Estrogen Stimulus Endocardial Cushion Morphogenesis Regulation Of Cell Cycle Phase Transition Response To Ether Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Magnesium Ion Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Protein Export From Nucleus Regulation Of Vesicle-mediated Transport Response To Immobilization Stress Heart Valve Development Regulation Of Mitotic Cell Cycle Atrioventricular Valve Morphogenesis Response To UV-C Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Supramolecular Fiber Organization Cytoplasmic Dynein Complex Microtubule Cytoskeleton Organization	None