CLVS2 and PHETA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLVS2	PHETA2
Description		clavesin 2	PH domain containing endocytic trafficking adaptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Trans-Golgi Network Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane	Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Bisphosphate Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Lysosome Organization	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways		Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		Refractive error ( 32231278) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		16 interacting genes: EMSY FBXW2 FLAD1 GSTM3 GSTZ1 GYS1 KAZN MEOX2 MYH7 PAFAH1B2 PCYT2 PGAM2 PHETA2 S100A7 S100A7A TACC2	1 interacting genes: CLVS2
Entrez ID		134829	150368
HPRD ID		16666	17305
Ensembl ID		ENSG00000146352	ENSG00000177096
Uniprot IDs		Q5SYC1	Q6ICB4
PDB IDs
Enriched GO Terms of Interacting Partners?		Catalytic Activity Transition Metal Ion Binding Glutathione Transferase Activity Identical Protein Binding Cytosol Maleylacetoacetate Isomerase Activity Ethanolamine-phosphate Cytidylyltransferase Activity FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity	Collagen Fibril Binding Negative Regulation Of Collagen Fibril Organization Phosphatidylinositol Bisphosphate Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Collagen Fibril Organization Phosphatidylinositol-3,5-bisphosphate Binding Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Cartilage Development Lysosome Organization Clathrin-coated Vesicle Regulation Of Cartilage Development Regulation Of Chondrocyte Differentiation Collagen Binding Regulation Of Extracellular Matrix Organization Trans-Golgi Network Membrane
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