CLVS2 and MYH7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLVS2	MYH7
Description		clavesin 2	myosin heavy chain 7
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Trans-Golgi Network Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane	Stress Fiber Cytoplasm Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Z Disc Myosin Filament Supramolecular Fiber
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Bisphosphate Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Lysosome Organization	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Lysosome Vesicle Biogenesis
Drugs			4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Mavacamten
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM) Myosin storage myopathy (MSM); Hyaline body myopathy Hypertrophic cardiomyopathy (HCM)
GWAS		Refractive error ( 32231278) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)	Atrial fibrillation ( 29892015 30061737) Resting heart rate ( 20639392 27798624)
Interacting Genes		16 interacting genes: EMSY FBXW2 FLAD1 GSTM3 GSTZ1 GYS1 KAZN MEOX2 MYH7 PAFAH1B2 PCYT2 PGAM2 PHETA2 S100A7 S100A7A TACC2	12 interacting genes: CHRM5 CLVS2 DISC1 KXD1 MYOM2 RND1 RNF167 SNAPIN TEAD1 TEAD3 TEAD4 TULP3
Entrez ID		134829	4625
HPRD ID		16666	01175
Ensembl ID		ENSG00000146352	ENSG00000092054
Uniprot IDs		Q5SYC1	P12883
PDB IDs			2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME 6PF2 6PFP 8ACT 8EFD 8EFE 8EFH 8EFI 8ENC 8G4L 8ZB7 8ZI9 9GZ1 9GZ2 9GZ3
Enriched GO Terms of Interacting Partners?		Catalytic Activity Transition Metal Ion Binding Glutathione Transferase Activity Identical Protein Binding Cytosol Maleylacetoacetate Isomerase Activity Ethanolamine-phosphate Cytidylyltransferase Activity FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity	Hippo Signaling Embryonic Organ Development Lysosome Localization Regulation Of Lysosome Size BORC Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane BLOC-1 Complex Regulation Of Vesicle Size Ciliary Base Transcription Regulator Complex Trophectodermal Cell Fate Commitment Positive Regulation Of Late Endosome To Lysosome Transport Lysosome Organization Neuron Cellular Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Animal Organ Development TEAD-YAP Complex Asymmetric Neuroblast Division Intraciliary Transport Particle A Binding Bronchus Morphogenesis Lysosomal Membrane Organelle Transport Along Microtubule Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone
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