PF4V1 and XCL1

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		PF4V1	XCL1
Description		platelet factor 4 variant 1	X-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483) Psoriasis ( 34927100)
Interacting Genes		15 interacting genes: CCL11 CCL19 CCL21 CCL22 CCL25 CCL26 CCL27 CCL28 CCL4L1 CXCL10 CXCL11 CXCL12 CXCL13 XCL1 XCL2	19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1
Entrez ID		5197	6375
HPRD ID		01427	02595
Ensembl ID		ENSG00000109272	ENSG00000143184
Uniprot IDs		P10720	P47992
PDB IDs		4HSV	1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Humoral Immune Response Granulocyte Chemotaxis Chemotaxis Locomotion Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration CCR Chemokine Receptor Binding Cell Killing Defense Response To Symbiont Defense Response To Other Organism Chemokine Receptor Binding Inflammatory Response Cell Migration Cytokine-mediated Signaling Pathway Cell Motility Response To Other Organism Immune Response Eosinophil Chemotaxis Eosinophil Migration Response To External Biotic Stimulus Defense Response Extracellular Space G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Mononuclear Cell Migration Regulation Of Locomotion Extracellular Region Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Negative Regulation Of Leukocyte Tethering Or Rolling Lymphocyte Migration Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Negative Regulation Of Cellular Extravasation Cell Surface Receptor Signaling Pathway	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication
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