PF4V1 and CCL27

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		PF4V1	CCL27
Description		platelet factor 4 variant 1	C-C motif chemokine ligand 27
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Neutrophil Chemotaxis Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Interacting Genes		15 interacting genes: CCL11 CCL19 CCL21 CCL22 CCL25 CCL26 CCL27 CCL28 CCL4L1 CXCL10 CXCL11 CXCL12 CXCL13 XCL1 XCL2	5 interacting genes: ACKR2 CCL11 CCL5 CCR10 PF4V1
Entrez ID		5197	10850
HPRD ID		01427	05321
Ensembl ID		ENSG00000109272	ENSG00000213927
Uniprot IDs		P10720	Q5VZ77 Q9Y4X3
PDB IDs		4HSV	2KUM
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Humoral Immune Response Granulocyte Chemotaxis Chemotaxis Locomotion Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration CCR Chemokine Receptor Binding Cell Killing Defense Response To Symbiont Defense Response To Other Organism Chemokine Receptor Binding Inflammatory Response Cell Migration Cytokine-mediated Signaling Pathway Cell Motility Response To Other Organism Immune Response Eosinophil Chemotaxis Eosinophil Migration Response To External Biotic Stimulus Defense Response Extracellular Space G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Mononuclear Cell Migration Regulation Of Locomotion Extracellular Region Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Negative Regulation Of Leukocyte Tethering Or Rolling Lymphocyte Migration Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Negative Regulation Of Cellular Extravasation Cell Surface Receptor Signaling Pathway	Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Granulocyte Chemotaxis Granulocyte Migration Cell Migration Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Migration Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis CCR Chemokine Receptor Binding Immune Response Antimicrobial Humoral Response Inflammatory Response Cytokine Activity Leukocyte Migration Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Chemokine Receptor Binding Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Dendritic Cell Chemotaxis Defense Response Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of T Cell Migration Intracellular Signaling Cassette Positive Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Actin Filament Polymerization Regulation Of T Cell Migration Regulation Of Granulocyte Chemotaxis ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Apoptotic Process Signal Transduction Response To Other Organism
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