PECAM1 and FOXJ1

Data Source: HiPPIP (Novel)

		PECAM1	FOXJ1
Name		platelet and endothelial cell adhesion molecule 1	forkhead box J1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Smooth Muscle Contractile Fiber Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Cell-cell Contact Zone Membrane Raft Extracellular Exosome Anchoring Junction Cell Periphery	Chromatin Nucleus
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Angiogenesis Blood Vessel Development Endothelial Cell Development Endothelial Cell Morphogenesis Phagocytosis Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Rho Protein Signal Transduction Cell Recognition Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Wound Healing Vasodilation Positive Regulation Of MAPK Cascade Endothelial Cell Migration Diapedesis Detection Of Mechanical Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Glomerular Endothelium Development Neutrophil Extravasation Endothelial Cell-matrix Adhesion Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation
Pathways		Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	None
GWAS		Appendicular lean mass ( 33097823 ) Coronary artery disease ( 29212778 32469254 33020668 ) Myocardial infarction ( 33532862 ) Pulse pressure ( 27841878 30578418 ) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189 ) Systolic blood pressure ( 27841878 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: BRIP1 FOXJ1	9 novel interactors: ATP10A CD79B CDK3 FBXO22 FKBP1A GATA6 PECAM1 PRKCA SMURF2
Interacting Genes		22 interacting genes: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1	8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2
Entrez ID		5175	2302
HPRD ID		01425	03798
Ensembl ID		ENSG00000261371	ENSG00000129654
Uniprot IDs		P16284	Q92949
PDB IDs		2KY5 5C14 5GNI	Not available
GO Terms Enriched among Interactors		T Cell Costimulation Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Cell Migration Activation Of Immune Response Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Regulation Of Cell Activation Cell Motility Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell-cell Junction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Immune Response Regulation Of Transport Positive Regulation Of Cell-cell Adhesion Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Phosphotyrosine Residue Binding Positive Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Cell Population Proliferation Cell Activation	None