ATP8A2

Description		ATPase phospholipid transporting 8A2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endosome Membrane Endomembrane System Membrane Cell Projection Phospholipid-translocating ATPase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Aminophospholipid Flippase Activity ATP Hydrolysis Activity Metal Ion Binding Phosphatidylethanolamine Flippase Activity Phosphatidylserine Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Phosphatidylserine Flippase Activity
	Biological Process	Involuntary Skeletal Muscle Contraction Lipid Transport Axonogenesis Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Retina Layer Formation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Phospholipid Transport Positive Regulation Of Multicellular Organism Growth Inner Ear Morphogenesis Eating Behavior Skin Development Phospholipid Translocation Neuron Development Neuromuscular Process Controlling Posture Detection Of Light Stimulus Involved In Visual Perception Neurofilament Cytoskeleton Organization Positive Regulation Of Phospholipid Translocation Aminophospholipid Translocation
Pathways		Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Common carotid intima-media thickness ( 29206233) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Eating disorders ( 23568457) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978)
Interacting Genes		1 interacting genes: UIMC1
Entrez ID		51761
HPRD ID		05795
Ensembl ID		ENSG00000132932
Uniprot IDs		A0A804HI09 A0A804HKW9 B7Z880 Q6ZU25 Q9NTI2
PDB IDs
Enriched GO Terms of Interacting Partners?		BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DNA Repair-dependent Chromatin Remodeling K63-linked Polyubiquitin Modification-dependent Protein Binding Mitotic G2 DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Site Of Double-strand Break Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Positive Regulation Of DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Histone Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition
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