CAB39 and CFLAR

		CAB39	CFLAR
Description		calcium binding protein 39	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Z Disc Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Serine/threonine Protein Kinase Complex Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein Serine/threonine Kinase Binding	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding
	Biological Process	Signal Transduction Response To Activity Intracellular Signal Transduction Cellular Hypotonic Response Response To Thyroid Hormone Negative Regulation Of Potassium Ion Transmembrane Transport	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Energy dependent regulation of mTOR by LKB1-AMPK Neutrophil degranulation	TRAIL signaling
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)
Interacting Genes		13 interacting genes: CEBPA CEP44 GOLGA2 IPO5 MCCD1 MED7 PRKAA1 RSL1D1 SHMT2 STK11 STK24 STRADA STRADB	34 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CUL1 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 MEX3B NEURL3 NFKB1 PSEN2 RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8
Entrez ID		51719	8837
HPRD ID		10091	04671
Ensembl ID		ENSG00000135932	ENSG00000003402
Uniprot IDs		Q9Y376	A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		1UPK 1UPL 2WTK 3GNI 4FZA 4FZD 4FZF 4NZW 4O27 8VSU	2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Organelle Disassembly Serine/threonine Protein Kinase Complex Regulation Of Protein Metabolic Process Intracellular Protein-containing Complex Activation Of Protein Kinase Activity Negative Regulation Of Translational Initiation Negative Regulation Of Hepatocyte Apoptotic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Protein Kinase Activity G1 To G0 Transition Regulation Of Translational Initiation Macromolecule Metabolic Process Cadherin Binding Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Protein Phosphorylation Positive Regulation Of Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Phosphorylation Regulation Of Protein Localization To Nucleus Protein Export From Nucleus Regulation Of Translation Rescue Of Stalled Ribosome Intracellular Signal Transduction Negative Regulation Of Translation Protein Kinase Activator Activity Carbohydrate Homeostasis Macrophage Differentiation Glucose Homeostasis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Multicellular Organismal-level Homeostasis Centrosome Cycle Negative Regulation Of Glucosylceramide Biosynthetic Process L-allo-threonine Aldolase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Ribosome Disassembly Negative Regulation Of Immune Response Response To Ketone Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Negative Regulation Of Immune System Process Regulation Of Protein Kinase Activity Regulation Of Immune Response	Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production
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