ESM1 and VGLL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ESM1	VGLL3
Description		endothelial cell specific molecule 1	vestigial like family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Nucleus
	Molecular Function	Hepatocyte Growth Factor Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding	Protein Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010) Familial squamous cell lung carcinoma ( 29924316) Sense of smell ( 26632684) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Adventurousness ( 30643258) Breast cancer ( 29059683) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Menarche (age at onset) ( 27182965 21102462) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 26443449 31562322) Pubertal anthropometrics ( 23449627) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		16 interacting genes: ADAM12 ANKS1A AQP1 BANP CTNNB1 FAM124B FRS3 HDAC7 HOXA1 ITGB2 MEOX2 NRF1 NUFIP2 PRKAB2 VGLL3 YY1	65 interacting genes: CDPF1 CERCAM CNFN CTRC CYSRT1 DTX2 ESM1 FAM168B FRS3 HGS INCA1 KPRP KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-6 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LASP1 LENG8 MDFI MYO15B OXER1 PCSK5 PITX1 PITX2 PLA2G10 POGZ POU2AF1 PRR22 RBPMS RUSC1 SMARCC1 SMOC1 SPMIP9 TBX15 TEAD1 TEAD2 TEAD3 TEAD4 TRIM42 TSC1 TSPAN4 UFSP1 YPEL3 ZNF34
Entrez ID		11082	389136
HPRD ID		03310	13431
Ensembl ID		ENSG00000164283	ENSG00000206538
Uniprot IDs		Q9NQ30	A8MV65
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Vasculature Development Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Glomerulus Vasculature Development Regulation Of Angiogenesis Eye Morphogenesis Epithelium Development Camera-type Eye Morphogenesis Nitric Oxide Transmembrane Transporter Activity Vasculature Development Metanephric Proximal Convoluted Tubule Segment 2 Development Ephrin Receptor Binding Glycerol Transmembrane Transporter Activity Corticotropin Secretion Mesenchymal Stem Cell Differentiation Nucleoplasm Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Embryonic Pattern Specification Vasculogenesis SMAD Binding Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Protein Kinase Binding Renal Outer Medulla Development Renal Vesicle Formation Fibroblast Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development DNA-binding Transcription Factor Binding Limb Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Regulation Of Cell Migration Involved In Sprouting Angiogenesis Immunoglobulin Heavy Chain V-D-J Recombination Sensory Organ Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Saliva Secretion Nucleus	Intermediate Filament Keratin Filament Hippo Signaling Embryonic Organ Development TEAD-YAP Complex Protein Binding Transcription Regulator Complex
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