VGLL1 and TEAD4

Number of citations of the paper that reports this interaction (PMID 10518497)
19

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		VGLL1	TEAD4
Gene Name		vestigial-like family member 1	TEA domain family member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm
	Molecular Function	Transcription Coactivator Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Muscle Organ Development Gene Expression Hippo Signaling
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Narcolepsy with cataplexy ( 23496005)
Protein-Protein Interactions		4 interactors: TEAD1 TEAD2 TEAD3 TEAD4	18 interactors: CCDC172 CCDC85B CCNDBP1 CEP55 CEP70 GOLGA2 KIAA0753 LZTS2 MYH7 PNMA1 RABGEF1 SSX2IP TRAF1 TRIM27 VGLL1 VPS52 WWTR1 YAP1
Entrez ID		51442	7004
HPRD ID		06751	03421
Ensembl ID		ENSG00000102243	ENSG00000197905
Uniprot IDs		Q99990	D3DUQ6 Q15561
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Positive Regulation Of Stem Cell Maintenance Transcription Initiation From RNA Polymerase II Promoter Regulation Of Stem Cell Maintenance DNA-templated Transcription, Initiation Positive Regulation Of Stem Cell Differentiation Lateral Mesoderm Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Notochord Development Paraxial Mesoderm Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Embryonic Heart Tube Morphogenesis Embryonic Heart Tube Development Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Development Positive Regulation Of Cell Differentiation Mesoderm Development RNA Metabolic Process Mesenchyme Development Embryo Development Positive Regulation Of Metabolic Process Gene Expression Heart Morphogenesis Cellular Macromolecule Biosynthetic Process Female Pregnancy Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Epithelial Tube Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Tube Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process	Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Hippo Signaling Negative Regulation Of Protein Transport Negative Regulation Of Cytokine Secretion Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Kit Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Mitotic Cell Cycle Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Interleukin-2 Secretion Embryonic Ectodermal Digestive Tract Development Cell Cycle Regulation Of Protein Localization Negative Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Phosphorylation Cytokinesis Cell Division Negative Regulation Of Intracellular Transport Regulation Of Fat Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation Regulation Of Cytokine Secretion Regulation Of Epithelial Cell Differentiation Negative Regulation Of Calcium Ion Import Negative Regulation Of Mast Cell Activation Involved In Immune Response Intraciliary Transport Involved In Cilium Morphogenesis Ectodermal Cell Differentiation Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Secretion By Cell Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma Secretion Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Ubiquitination Negative Regulation Of Secretion Negative Regulation Of Signaling Regulation Of Signal Transduction Spindle Midzone Assembly Protein Modification By Small Protein Conjugation
Tagcloud ?		atlas bbox1 brca1 c6orf211 carcinomas coordinated dataset esr1 foxa1 foxc1 frozen gabrp gata3 hippo intronic luminal microarrays mirna occasionally prom1 seq slc6a14 sporadic structurally taz tcga tn vestigial yap	amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap yap1
Tagcloud (Difference) ?		atlas bbox1 brca1 c6orf211 carcinomas coordinated dataset esr1 foxa1 foxc1 frozen gabrp gata3 intronic luminal microarrays mirna occasionally prom1 seq slc6a14 sporadic structurally taz tcga tn vestigial	amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap1
Tagcloud (Intersection) ?		hippo yap