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ANAPC7 and ANAPC4
Number of citations of the paper that reports this interaction (PMID
12956947
)
61
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical)
ANAPC7
ANAPC4
Gene Name
anaphase promoting complex subunit 7
anaphase promoting complex subunit 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Protein Phosphatase Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Phosphatase Binding
Biological Process
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Weight (
20966902
)
Protein-Protein Interactions
14 interactors:
ANAPC10
ANAPC2
ANAPC4
BUB1B
CDC16
CDC20
CDC27
CDH1
CDT1
CREBBP
FBXO5
FZR1
UBC
UBE2S
6 interactors:
ANAPC5
ANAPC7
CDH1
FBXO5
FZR1
UBE2S
Entrez ID
51434
29945
HPRD ID
16233
09505
Ensembl ID
ENSG00000196510
ENSG00000053900
Uniprot IDs
Q4KMX6
Q69YV3
Q9UJX3
E9PCR4
Q9UJX5
PDB IDs
3FFL
Enriched GO Terms of Interacting Partners
?
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Cell Cycle Checkpoint
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Mitotic Cell Cycle Process
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Sister Chromatid Separation
Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Protein Catabolic Process
Regulation Of Cell Division
Cell Division
Negative Regulation Of Cellular Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Cell Cycle Process
Spindle Assembly Checkpoint
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Mitotic Spindle Checkpoint
Positive Regulation Of Proteolysis
Protein Polyubiquitination
Negative Regulation Of Chromosome Segregation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Regulation Of Mitotic Metaphase/anaphase Transition
Cellular Macromolecule Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Negative Regulation Of Protein Ubiquitination
Cell Division
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Polyubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Transferase Activity
Cellular Protein Catabolic Process
Protein Catabolic Process
Activation Of Anaphase-promoting Complex Activity
Positive Regulation Of Protein Catabolic Process
Mitotic Cell Cycle Process
Regulation Of Cell Division
Mitotic Cell Cycle
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Cellular Macromolecule Catabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Protein Catabolic Process
Cell Cycle Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Process
Cell Cycle
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteolysis
Positive Regulation Of Catalytic Activity
Regulation Of Proteolysis
Regulation Of Meiosis
Cell Cycle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
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Tagcloud (Intersection)
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