NME8 and RIPK3

Number of citations of the paper that reports this interaction (PubMedID 29883609)
0

Data Source:
BioGRID (pull down)

		NME8	RIPK3
Description		NME/NM23 family member 8	receptor interacting serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axoneme Nuclear Speck Sperm Flagellum Outer Dynein Arm Sperm Midpiece Sperm Principal Piece Sperm Cytoplasmic Droplet	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Microtubule Binding 3'-5'-DNA Exonuclease Activity Hydrolase Activity	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity
	Biological Process	DNA Catabolic Process Spermatogenesis Cell Differentiation Flagellated Sperm Motility Cellular Response To Reactive Oxygen Species Cilium Assembly	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Gene Expression Programmed Cell Death Activation Of Protein Kinase Activity Regulation Of Type II Interferon Production T Cell Differentiation In Thymus Protein Modification Process Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Periodontitis ( 25672891)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		2 interacting genes: APP RIPK3	24 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 TRAF6 TRIM25 UTP11 XIAP ZSCAN20
Entrez ID		51314	11035
HPRD ID		16243	09315
Ensembl ID		ENSG00000086288	ENSG00000129465
Uniprot IDs		Q8N427	Q9Y572
PDB IDs			5V7Z 5ZCK 7DA4 7DAC 7MON 7MX3
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of T Cell Migration Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Succinate-hydroxymethylglutarate CoA-transferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Leukocyte Migration Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Activation-induced Cell Death Of T Cells Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Positive Regulation Of Necroptotic Process BBSome Heparan Sulfate Binding Signaling Receptor Activator Activity	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Necroptotic Process Regulation Of Protein Modification Process Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Receptor Complex Ubiquitin Protein Ligase Activity Regulation Of Defense Response Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Defense Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Protein K63-linked Ubiquitination Signaling Adaptor Activity Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Ripoptosome
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