NME8

Description		NME/NM23 family member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axoneme Nuclear Speck Sperm Flagellum Outer Dynein Arm Sperm Midpiece Sperm Principal Piece Sperm Cytoplasmic Droplet
	Molecular Function	Microtubule Binding 3'-5'-DNA Exonuclease Activity Hydrolase Activity
	Biological Process	DNA Catabolic Process Spermatogenesis Cell Differentiation Flagellated Sperm Motility Cellular Response To Reactive Oxygen Species Cilium Assembly
Pathways
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Periodontitis ( 25672891)
Novel Interacting Genes		2 novel interacting genes: BBS9 SUGCT
Interacting Genes		2 interacting genes: APP RIPK3
Entrez ID		51314
HPRD ID		16243
Ensembl ID		ENSG00000086288
Uniprot IDs		Q8N427
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of T Cell Migration Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Succinate-hydroxymethylglutarate CoA-transferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Leukocyte Migration Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Activation-induced Cell Death Of T Cells Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Positive Regulation Of Necroptotic Process BBSome Heparan Sulfate Binding Signaling Receptor Activator Activity
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