ZDHHC2 and MSX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZDHHC2	MSX2
Gene Name		zinc finger, DHHC-type containing 2	msh homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Recycling Endosome Membrane	Nucleus Transcription Factor Complex
	Molecular Function	Zinc Ion Binding Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Cofactor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Protein Palmitoylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of CREB Transcription Factor Activity Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Catagen Bone Trabecula Formation Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis BMP Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MAFB MSX2	21 interactors: ATXN1 CEBPA DLX2 DLX5 GTF2F1 GTF2F2 MAGED1 MSX1 NR3C1 PIAS2 POLR3D POU2AF1 PPARG RUNX2 SPEN TLE1 TLE2 XRCC5 XRCC6 ZBTB17 ZDHHC2
Entrez ID		51201	4488
HPRD ID		15715	00421
Ensembl ID			ENSG00000120149
Uniprot IDs		Q9UIJ5	P35548
PDB IDs
Enriched GO Terms of Interacting Partners?		Rhombomere 6 Development Brain Segmentation Positive Regulation Of Mesenchymal Cell Apoptotic Process Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of Catagen Embryonic Nail Plate Morphogenesis Rhombomere 5 Development Activation Of Meiosis Frontal Suture Morphogenesis BMP Signaling Pathway Involved In Heart Development Pattern Specification Process Gland Development Negative Regulation Of Keratinocyte Differentiation Enamel Mineralization Nail Development Embryonic Morphogenesis Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Hair Follicle Development Tooth Mineralization Rhombomere Development Bone Trabecula Formation Negative Regulation Of Cell Differentiation Wound Healing, Spreading Of Epidermal Cells Cranial Suture Morphogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Amelogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding Craniofacial Suture Morphogenesis Segment Specification Regulation Of Hair Follicle Development Positive Regulation Of Meiotic Nuclear Division Endocardial Cushion Formation Bone Trabecula Morphogenesis Cellular Response To Estradiol Stimulus Organ Morphogenesis Regulation Of Hair Cycle Endocardial Cushion Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Cardiac Epithelial To Mesenchymal Transition Osteoblast Development Embryo Development Regulation Of Keratinocyte Differentiation Cellular Response To Estrogen Stimulus Endochondral Bone Growth Positive Regulation Of Epidermis Development Chondrocyte Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Differentiation	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Cellular Hyperosmotic Salinity Response DNA-templated Transcription, Initiation Organ Development Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Multicellular Organismal Development Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Differentiation Viral Process Regulation Of Signal Transduction Anatomical Structure Development System Development
Tagcloud ?			achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher
Tagcloud (Difference) ?			achondroplasia attendant clefts collins craniosynostosis crest crouzon deformities dentofacial detoxifying excessively ganglionic hemifacial holoprosencephaly jaws kills malocclusions merging microsomia mismatches neuromeres ordinated palatal placodal placodes prominences radically shelves treacher
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