DCTN4 and ATP7B

Number of citations: 0 (PubMedID 16554302)
Data Source: BioGRID (two hybrid, affinity chromatography technology), HPRD (in vivo, two hybrid)

		DCTN4	ATP7B
Name		dynactin subunit 4	ATPase copper transporting beta
Structure		No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Dynactin Complex Focal Adhesion Cell Cortex Sarcomere	Golgi Membrane Cytoplasm Mitochondrion Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity P-type Divalent Copper Transporter Activity Metal Ion Binding P-type Monovalent Copper Transporter Activity
	Biological Process	None	Monoatomic Ion Transport Monoatomic Cation Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Lactation Copper Ion Import Monoatomic Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Protein Maturation Establishment Of Localization In Cell Copper Ion Export Viral Translational Frameshifting Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Ion transport by P-type ATPases
Diseases		None	Wilson disease; Hepatolenticular degeneration
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Dimensional psychopathology (Arousal) ( 29496196 ) Inflammatory bowel disease ( 28067908 ) Lung adenocarcinoma ( 28604730 )	Clostridium difficile infection in multiple myeloma ( 29594489 ) Mean spheric corpuscular volume ( 32888494 ) Waist circumference adjusted for body mass index ( 28552196 )
Interacting Genes		8 interacting genes: ACTR10 ACTR1A ATP7B CALCOCO2 GOLGA2 HMG20A MTUS2 PNMA1	4 interacting genes: ATOX1 DCTN4 HP ZBTB16
Entrez ID		51164	540
HPRD ID		13126	06050
Ensembl ID		ENSG00000132912	ENSG00000123191
Uniprot IDs		A0A0S2Z5D4 Q9UJW0	A0A669KB88 A0AAQ5BGL6 A0AAQ5BGP2 B7ZLR3 B7ZLR4 E7ET55 F5H562 F5H748 P35670
PDB IDs		Not available	2ARF 2EW9 2KOY 2LQB 2N7Y 2ROP 6A71 6A72 7XUK 7XUM 7XUN 7XUO 8IOY
GO Terms Enriched among Interactors		Dynactin Complex Cytoskeleton	Copper-dependent Protein Binding Copper Ion Export Copper Chaperone Activity Metallochaperone Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Hemoglobin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of NK T Cell Differentiation Copper Ion Transmembrane Transport Dynactin Complex Cuprous Ion Binding Ossification Involved In Bone Maturation Response To Oxidative Stress Haptoglobin-hemoglobin Complex Mesonephros Development Asymmetric Cell Division Copper Ion Transport Intracellular Copper Ion Homeostasis Regulation Of Hydrogen Peroxide Metabolic Process Endocytic Vesicle Lumen Copper Ion Homeostasis Positive Regulation Of Chondrocyte Differentiation Cytoplasmic Dynein Complex Stem Cell Division Antioxidant Activity