REXO1 and PAFAH1B2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		REXO1	PAFAH1B2
Gene Name		REX1, RNA exonuclease 1 homolog (S. cerevisiae)	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleic Acid Binding Exonuclease Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Nucleic Acid Phosphodiester Bond Hydrolysis	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: PAFAH1B2 RLIM TCEA1 TCEB3	14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1
Entrez ID		57455	5049
HPRD ID		15478	03940
Ensembl ID		ENSG00000079313	ENSG00000168092
Uniprot IDs		Q8N1G1	P68402
PDB IDs			1VYH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Random Inactivation Of X Chromosome Regulation Of Viral Process Translational Elongation Regulation Of Transcription From RNA Polymerase II Promoter Dosage Compensation By Inactivation Of X Chromosome Dosage Compensation Positive Regulation Of Macroautophagy Viral Process Transcription, DNA-templated RNA Biosynthetic Process Translation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Autophagy Transcription-coupled Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of DNA-templated Transcription, Elongation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation
Tagcloud ?			1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?			1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Intersection) ?