GAL and ASPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GAL	ASPH
Description		galanin and GMAP prepropeptide	aspartate beta-hydroxylase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Neuronal Cell Body	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Galanin Receptor Activity Hormone Activity Neuropeptide Hormone Activity Protein Binding Galanin Receptor Binding Type 1 Galanin Receptor Binding Type 2 Galanin Receptor Binding Type 3 Galanin Receptor Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Neuropeptide Signaling Pathway Nervous System Development Feeding Behavior Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Protein Kinase A Signaling Insulin Secretion Regulation Of Glucocorticoid Metabolic Process Response To Insulin Response To Immobilization Stress Positive Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lymphocyte Proliferation Positive Regulation Of Cortisol Secretion Positive Regulation Of Timing Of Catagen Parental Behavior Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs			Aspartic acid
Diseases
GWAS		Femoral neck section modulus ( 30888730) Height ( 28552196) Serum metabolite levels ( 33031748)	Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		7 interacting genes: ASPH GALR1 GALR2 GPR151 SGTA UBQLN1 UBQLN2	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		51083	444
HPRD ID		00658	08996
Ensembl ID		ENSG00000069482	ENSG00000198363
Uniprot IDs		P22466	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs		7S3O 7S3Q 7S3R 7WQ3 7WQ4 7XBD 7XJJ 7XJK 8DHZ 8DJ4	5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Galanin Receptor Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Peptide Hormone Binding Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G Protein-coupled Receptor Activity Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Galanin-activated Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Autophagosome Assembly Proteasomal Protein Catabolic Process Neuropeptide Signaling Pathway Autophagosome Organization Peptidyl-aspartic Acid 3-dioxygenase Activity TRC Complex Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cellular Response To Stress Positive Regulation Of Catabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Membrane Positive Regulation Of Cortisol Secretion BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Activation Of Store-operated Calcium Channel Activity Proteolysis Involved In Protein Catabolic Process	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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