PCK1 and RAE1

		PCK1	RAE1
Description		phosphoenolpyruvate carboxykinase 1	ribonucleic acid export 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding Kinase Activity Transferase Activity Lyase Activity Carboxy-lyase Activity Purine Nucleotide Binding Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding Protein Serine Kinase Activity (using GTP As Donor)	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding
	Biological Process	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Response To Bacterium Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP-SCAP Complex Retention In Endoplasmic Reticulum Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Dicarboxylic Acid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Glyceraldehyde-3-phosphate Biosynthetic Process Glycerol Biosynthetic Process From Pyruvate Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Protein Maturation Hepatocyte Differentiation Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Tricarboxylic Acid Metabolic Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization
Pathways		Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate
Diseases
GWAS		Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Interacting Genes		8 interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 UBR5	14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1
Entrez ID		5105	8480
HPRD ID		02028	11939
Ensembl ID		ENSG00000124253	ENSG00000101146
Uniprot IDs		P35558	P78406
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV	3MMY 4OWR 7F60 7F90 7VPG 7VPH
Enriched GO Terms of Interacting Partners?		SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Cholesterol Biosynthetic Process NLS-bearing Protein Import Into Nucleus Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Steroid Biosynthetic Process SREBP-SCAP-Insig Complex Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Cholesterol Metabolic Process Maintenance Of Protein Location In Cell Regulation Of Cellular Response To Stress Maintenance Of Protein Location Nuclear Transport Nucleocytoplasmic Transport Maintenance Of Location In Cell Cranial Suture Morphogenesis Maintenance Of Location Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Response To Endoplasmic Reticulum Stress Protein Maturation Response To Sterol Depletion Anoikis Regulation Of Small Molecule Metabolic Process Cellular Response To Insulin Stimulus Protein K29-linked Ubiquitination Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Small Molecule Metabolic Process Oxysterol Binding Protein Import Into Nucleus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Import Into Nucleus Establishment Of Localization In Cell Craniofacial Suture Morphogenesis Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process	MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?