GLRX2 and ELF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLRX2	ELF5
Description		glutaredoxin 2	E74 like ETS transcription factor 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Chromatin Nucleus Cytoplasm
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein-disulfide Reductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Glutathione Metabolic Process Apoptotic Process Response To Temperature Stimulus Regulation Of Signal Transduction Cell Differentiation DNA Protection Cell Redox Homeostasis Response To Redox State	Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ectoderm Development Cell Differentiation Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Mammary Gland Epithelial Cell Differentiation Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Pathways			Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Glutathione
Diseases
GWAS			β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: DCXR ELF5 FBXO7 TXNRD1	11 interacting genes: ACTR2 CRBN FRZB GLRX2 NFE2 NFE2L2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4
Entrez ID		51022	2001
HPRD ID		12112	05525
Ensembl ID		ENSG00000023572	ENSG00000135374
Uniprot IDs		Q9NS18	A0A087X1W9 A8K443 Q9UKW6
PDB IDs		2CQ9 2FLS 2HT9	1WWX
Enriched GO Terms of Interacting Partners?		NADPH Peroxidase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite L-xylulose Reductase (NADPH) Activity Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Ectodermal Cell Fate Commitment Xylulose Metabolic Process Protein Localization To Nuclear Pore Lewy Body Core D-xylose Metabolic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Oxidoreductase Activity, Acting On CH-OH Group Of Donors D-glucuronate Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Nuclear Pore Central Transport Channel Thioredoxin-disulfide Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carbonyl Reductase (NADPH) Activity Positive Regulation Of T-helper 2 Cell Cytokine Production Pentose Metabolic Process	Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cellular Component Organization Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Integrated Stress Response Signaling Nucleus Positive Regulation Of Cellular Component Organization Cell Redox Homeostasis Regulation Of Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Regulation Of DNA Repair Site Of DNA Damage Negative Regulation Of Hepatocyte Differentiation Positive Regulation Of Glutathione Biosynthetic Process Regulation Of D-glucose Import Arsenate Reductase (glutaredoxin) Activity Histone H3K56 Deacetylase Activity, NAD-dependent Positive Regulation Of Fat Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Differentiation Regulation Of Glutathione Biosynthetic Process Regulation Of D-glucose Transmembrane Transport Aflatoxin Catabolic Process Glutathione Disulfide Oxidoreductase Activity Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism Chromosome, Subtelomeric Region Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein Depalmitoylase Activity Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity Nuclear Proteasome Complex Positive Regulation Of Cell Projection Organization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Double-strand Break Repair Site Of Double-strand Break Cellular Response To Stress Regulation Of RNA Metabolic Process Meiotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagosome Maturation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Proteasomal Ubiquitin-independent Protein Catabolic Process
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