CDON and CDH2

Number of citations of the paper that reports this interaction (PMID 12634428)
25

Data Source:
HPRD (in vivo)

		CDON	CDH2
Gene Name		cell adhesion associated, oncogene regulated	cadherin 2, type 1, N-cadherin (neuronal)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Matrix	Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Fascia Adherens Focal Adhesion Intercalated Disc Integral Component Of Membrane Apical Plasma Membrane Catenin Complex Lamellipodium Synapse Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Alpha-catenin Binding Gamma-catenin Binding
	Biological Process	Cell Fate Specification Positive Regulation Of Protein Phosphorylation Lens Development In Camera-type Eye Cell Adhesion Smoothened Signaling Pathway Myoblast Fusion Anterior/posterior Pattern Specification Embryonic Body Morphogenesis Skeletal Muscle Satellite Cell Differentiation Cerebral Cortex Development Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of Protein Heterodimerization Activity Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glial Cell Differentiation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Cell Junction Assembly Adherens Junction Organization Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization Blood Vessel Morphogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance
Pathways		CDO in myogenesis Myogenesis Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions	Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Adherens junctions interactions
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 22881374) Primary tooth development (time to first tooth eruption) ( 23704328)	Obesity-related traits ( 23251661) Temperament (bipolar disorder) ( 22365631) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		5 interactors: ABL1 BOC CDH15 CDH2 CTNNB1	22 interactors: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1
Entrez ID		50937	1000
HPRD ID		16372	00226
Ensembl ID		ENSG00000064309	ENSG00000170558
Uniprot IDs		Q4KMG0	A8MWK3 P19022
PDB IDs		3D1M 3N1F 3N1Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Muscle Cell Differentiation Muscle Structure Development Positive Regulation Of Cell Differentiation Cell Adhesion Adherens Junction Organization Regulation Of Cell Differentiation Glial Cell Differentiation Cell Junction Assembly Cell-cell Junction Organization Gliogenesis Regulation Of Wnt Signaling Pathway Locomotion Thymus Development Positive Regulation Of MAPK Cascade Cell Differentiation Movement Of Cell Or Subcellular Component Single Organismal Cell-cell Adhesion Neurogenesis Cell Development Regulation Of MAPK Cascade Cellular Component Assembly Transitional One Stage B Cell Differentiation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Development Stem Cell Maintenance T Cell Differentiation Negative Regulation Of Phospholipase C Activity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Mitochondrial Depolarization Nervous System Development Cell Migration Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Phosphorylation Anatomical Structure Morphogenesis Cell Motility Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Cellular Response To Dopamine Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination	Cellular Response To Indole-3-methanol Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Cell Adhesion Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Multicellular Organismal Development Regulation Of Signal Transduction Positive Regulation Of Muscle Cell Differentiation Anatomical Structure Morphogenesis Cellular Response To Organonitrogen Compound Regulation Of Cell Differentiation Single Organismal Cell-cell Adhesion Developmental Process Response To Organonitrogen Compound Cellular Response To Stimulus Cell Differentiation Anatomical Structure Development Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Muscle Cell Differentiation Response To Stimulus Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glutamate Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Platelet Activation Neuron-neuron Synaptic Transmission Embryonic Digit Morphogenesis Regulation Of Cell Morphogenesis Regulation Of Neural Precursor Cell Proliferation Locomotion Regulation Of Intracellular Signal Transduction Epithelial Cell-cell Adhesion Cell-cell Junction Assembly Enzyme Linked Receptor Protein Signaling Pathway Axon Development Cell-cell Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Homeostatic Process Cellular Component Assembly Protein Heterooligomerization Regulation Of Cell Fate Specification Cellular Response To Peptide Hormone Stimulus Muscle Cell Differentiation Regulation Of MAPK Cascade
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	bioinformatics blotting cadherin downregulating embedded expressions fixed formalin igf1r immunohistochemistry lentiviruses luciferase metastasis mir os osteosarcoma paraffin paraformalin partially predicted probably promising prove quantitative real reporter sosp transfected u2
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	bioinformatics blotting cadherin downregulating embedded expressions fixed formalin igf1r immunohistochemistry lentiviruses luciferase metastasis mir os osteosarcoma paraffin paraformalin partially predicted probably promising prove quantitative real reporter sosp transfected u2
Tagcloud (Intersection) ?