ATP5F1C and ERCC6

Number of citations of the paper that reports this interaction (PubMedID 31722399)
57

Data Source:
BioGRID (pull down)

		ATP5F1C	ERCC6
Description		ATP synthase F1 subunit gamma	ERCC excision repair 6, chromatin remodeling factor
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Proton-transporting ATP Synthase Complex	Nucleus Nucleoplasm Chromosome Nucleolus Transcription Elongation Factor Complex Nuclear Body Site Of DNA Damage B-WICH Complex
	Molecular Function	RNA Binding Protein Binding ATP Hydrolysis Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Nucleotide Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding RNA Polymerase Binding Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Oxidative Phosphorylation ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Positive Regulation Of Defense Response To Virus By Host DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II DNA Damage Response Response To Oxidative Stress JNK Cascade Nervous System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Positive Regulation Of Gene Expression Protein Ubiquitination Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Transcription Elongation By RNA Polymerase II Multicellular Organism Growth DNA Protection Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription Initiation By RNA Polymerase II Protein Localization To Chromatin Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		30 interacting genes: APP ATP5F1A ATP5F1B CA12 CCND3 CCT7 CDC42 CHMP2B DPP3 DUX4 EGFR ELOF1 ERCC6 FAM120A FBXO7 GDPD2 ITIH2 MED15 MEOX2 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTEN PTN SERPINA1 ZNF337	117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 DCLRE1A ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38
Entrez ID		509	2074
HPRD ID		00156	00596
Ensembl ID		ENSG00000165629	ENSG00000225830
Uniprot IDs		B4DL14 P36542 Q8TAS0	P0DP91 Q03468 Q59FF6
PDB IDs		8H9E 8H9F 8H9I 8H9J 8H9L 8H9M 8H9P 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3	4CVO 6A6I 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Cell Cycle Angiostatin Binding Regulation Of Peptidyl-serine Phosphorylation Regulation Of Endothelial Cell Migration Regulation Of Cell Cycle Process Positive Regulation Of Cell Migration Proton-transporting Two-sector ATPase Complex Neuron Projection Organization Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Postsynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Long-term Synaptic Potentiation Proton Motive Force-driven Mitochondrial ATP Synthesis Estrous Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Transcription-coupled Nucleotide-excision Repair Cognition Regulation Of Mitotic Cell Cycle Proton Motive Force-driven ATP Synthesis Transmembrane Transporter Complex Negative Regulation Of Cell Population Proliferation Proton-transporting ATP Synthase Activity, Rotational Mechanism Regulation Of Cell Cycle G1/S Phase Transition Regulation Of MiRNA Transcription ATP Biosynthetic Process Protein Tyrosine Kinase Activator Activity Negative Regulation Of Cell Cycle Regulation Of MiRNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Serine-type Endopeptidase Inhibitor Activity Regulation Of Epithelial Cell Proliferation MHC Class I Protein Binding Ovulation Cycle Dendritic Spine Morphogenesis Nervous System Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Auditory Stimulus Proton-transporting ATP Synthase Complex Transcription Elongation Factor Complex Positive Regulation Of Peptidyl-serine Phosphorylation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process	Translation Ribosome Macromolecule Metabolic Process RNA Binding Macromolecule Biosynthetic Process Structural Constituent Of Ribosome Ribonucleoprotein Complex Mitochondrial Translation Nucleoplasm Protein Metabolic Process NuRD Complex Mitochondrial Large Ribosomal Subunit Mitochondrial Inner Membrane Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Nucleus Protein-RNA Complex Assembly Cytosolic Ribosome Ubiquitin Protein Ligase Binding Nucleic Acid Metabolic Process PML Body Regulation Of Stem Cell Differentiation Small Protein Activating Enzyme Binding Cytoplasmic Translation Formation Of Cytoplasmic Translation Initiation Complex Chromosome, Telomeric Region Eukaryotic Translation Initiation Factor 3 Complex Nucleobase-containing Compound Metabolic Process Eukaryotic 48S Preinitiation Complex Protein Sumoylation Mitochondrion Eukaryotic 43S Preinitiation Complex Cytoplasmic Translational Initiation Chromatin Organization Protein-containing Complex Nucleosomal DNA Binding Nucleolus DNA Repair Chromatin Remodeling Mitochondrial Ribosome Regulation Of Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Translational Initiation Nucleotide-excision Repair Protein-containing Complex Organization DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein-containing Complex Assembly Chromosome
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