RNF141 and TRIM24

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF141	TRIM24
Description		ring finger protein 141	tripartite motif containing 24
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GO Annotations	Cellular Component	Membrane	Chromatin Euchromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytosol Nuclear Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K23ac Reader Activity
	Biological Process	Regulation Of DNA-templated Transcription Protein Autoubiquitination	Chromatin Organization Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)
Interacting Genes		8 interacting genes: DTX3 KRAS MAP3K1 MVK PLK3 SMURF1 TRIM24 TRIM8	54 interacting genes: AKT1 AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 CREBBP ESR1 ESR2 FOSL1 GTF2E1 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRAF3 TRIM28 TRIM33 TRIM8 UBE2D1 UBE2I UBE2U VDR ZNF10
Entrez ID		50862	8805
HPRD ID		11509	04556
Ensembl ID		ENSG00000110315	ENSG00000122779
Uniprot IDs		Q8WVD5	O15164
PDB IDs		2ECN 5XEK	2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V 7B9X
Enriched GO Terms of Interacting Partners?		Transferase Activity Protein Modification Process Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation P53 Binding Positive Regulation Of Chaperone-mediated Autophagy Protein Metabolic Process Mevalonate Kinase Activity Histone H3K23ac Reader Activity Post-translational Protein Modification Engulfment Of Target By Autophagosome Cytoplasm Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Regulation Of Signal Transduction By P53 Class Mediator Endomitotic Cell Cycle GMP Binding Forebrain Astrocyte Development Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Isolation Stress Kinase Activity Isopentenyl Diphosphate Biosynthetic Process Isopentenyl Diphosphate Metabolic Process Perichromatin Fibrils Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Golgi Disassembly LRR Domain Binding Activin Receptor Binding Response To Gravity	Nucleoplasm Nuclear Receptor Activity Protein-DNA Complex Assembly Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Gene Expression Protein-containing Complex Epigenetic Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Protein Heterodimerization Activity Telomere Organization Estrogen Response Element Binding Nucleosome Organization Nuclear Steroid Receptor Activity Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II
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