RNF141 and DTX3

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF141	DTX3
Description		ring finger protein 141	deltex E3 ubiquitin ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Protein Autoubiquitination	Notch Signaling Pathway Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		8 interacting genes: DTX3 KRAS MAP3K1 MVK PLK3 SMURF1 TRIM24 TRIM8	46 interacting genes: ARF5 BAG3 DTX1 DTX2 EPHB4 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19
Entrez ID		50862	196403
HPRD ID		11509	16842
Ensembl ID		ENSG00000110315	ENSG00000178498
Uniprot IDs		Q8WVD5	Q8N9I9
PDB IDs		2ECN 5XEK
Enriched GO Terms of Interacting Partners?		Transferase Activity Protein Modification Process Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation P53 Binding Positive Regulation Of Chaperone-mediated Autophagy Protein Metabolic Process Mevalonate Kinase Activity Histone H3K23ac Reader Activity Post-translational Protein Modification Engulfment Of Target By Autophagosome Cytoplasm Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Regulation Of Signal Transduction By P53 Class Mediator Endomitotic Cell Cycle GMP Binding Forebrain Astrocyte Development Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Isolation Stress Kinase Activity Isopentenyl Diphosphate Biosynthetic Process Isopentenyl Diphosphate Metabolic Process Perichromatin Fibrils Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Golgi Disassembly LRR Domain Binding Activin Receptor Binding Response To Gravity	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Protein Monoubiquitination Macromolecule Catabolic Process Protein K63-linked Ubiquitination ATP Binding ISG15 Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleotide Binding ISG15-protein Conjugation Nucleus Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Cell Surface Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Ephrin Receptor Signaling Pathway UBC13-MMS2 Complex Regulation Of Signal Transduction Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein K63-linked Ubiquitination Protein Binding Protein Catabolic Process
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