DHH and HHIP

Number of citations of the paper that reports this interaction (PMID 10050855)
113

Data Source:
HPRD (in vivo)

		DHH	HHIP
Gene Name		desert hedgehog	hedgehog interacting protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane	Extracellular Region Cytoplasm Integral Component Of Plasma Membrane Cell Surface Ciliary Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding	Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, Quinone Or Similar Compound As Acceptor Quinone Binding Hedgehog Family Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Spermatid Development Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Regulation Of Steroid Biosynthetic Process	Carbohydrate Metabolic Process Smoothened Signaling Pathway Neuroblast Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Oxidation-reduction Process Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)	Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Height ( 20881960 19343178 23563607 18391950 18391951 18391952 20397748) Pulmonary function ( 20010834 20010835 19300500) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		3 interactors: HHIP PTCH1 PTCH2	3 interactors: DHH IHH SHH
Entrez ID		50846	64399
HPRD ID		05664	06937
Ensembl ID		ENSG00000139549
Uniprot IDs		O43323	Q96QV1
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q	2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Epithelium Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Branching Morphogenesis Of An Epithelial Tube Neural Plate Axis Specification Response To Chlorate Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Epithelial Tube Morphogenesis Tube Morphogenesis Cell Proliferation Involved In Metanephros Development Pattern Specification Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Morphogenesis Of An Epithelium Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Regulation Of Signal Transduction Cellular Response To Cholesterol Neural Plate Development Cellular Response To Sterol Tissue Morphogenesis Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Tube Development Response To Cholesterol Pharyngeal System Development Cell Proliferation Regulation Of Cholesterol Efflux Dorsal/ventral Neural Tube Patterning Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein Targeting To Plasma Membrane Organ Morphogenesis Spinal Cord Motor Neuron Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Osteoblast Differentiation Embryonic Axis Specification Neuroblast Proliferation Ventral Spinal Cord Development Hindlimb Morphogenesis	Intein-mediated Protein Splicing Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Alpha-beta T Cell Activation Embryonic Digestive Tract Morphogenesis Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Embryonic Digestive Tract Development Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Regulation Of Mesenchymal Cell Proliferation Patterning Of Blood Vessels Positive Regulation Of Smoothened Signaling Pathway Heart Looping Negative Regulation Of T Cell Proliferation Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Digestive Tract Morphogenesis Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Stem Cell Proliferation Developmental Process Involved In Reproduction Negative Regulation Of Leukocyte Proliferation Neuron Fate Commitment Positive Regulation Of T Cell Differentiation Embryonic Heart Tube Development Embryonic Pattern Specification Positive Regulation Of Lymphocyte Differentiation Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Cell-cell Signaling Negative Regulation Of Homotypic Cell-cell Adhesion Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Determination Of Bilateral Symmetry Smoothened Signaling Pathway Response To Estradiol Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Digestive Tract Development Osteoblast Differentiation Regulation Of T Cell Proliferation Digestive System Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation
Tagcloud ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes hedgehog helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian shh sonic suggestions vertebrate vertebrates wgd	augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis hedgehog heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation shh sonic tubulointerstitial ub ureteric
Tagcloud (Difference) ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian suggestions vertebrate vertebrates wgd	augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation tubulointerstitial ub ureteric
Tagcloud (Intersection) ?		hedgehog shh sonic