DHH and PTCH1

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		DHH	PTCH1
Gene Name		desert hedgehog	patched 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane	Golgi Apparatus Plasma Membrane Caveola Postsynaptic Density Integral Component Of Membrane Midbody Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Ciliary Membrane Primary Cilium
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein Complex Binding Hedgehog Family Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Spermatid Development Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Regulation Of Steroid Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Smoothened Signaling Pathway Regulation Of Mitotic Cell Cycle Brain Development Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Organ Morphogenesis Dorsal/ventral Pattern Formation Response To Chlorate Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinocyte Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Embryonic Organ Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Renal System Development Cell Proliferation Involved In Metanephros Development Protein Targeting To Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Metabolic disorders of biological oxidation enzymes GPCR ligand binding Ligand-receptor interactions Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)	Height ( 18391952) Pulmonary function ( 20010835) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		3 interactors: HHIP PTCH1 PTCH2	7 interactors: CCNB1 CDK1 DHH HIPK2 IHH SHH SMO
Entrez ID		50846	5727
HPRD ID		05664	03200
Ensembl ID		ENSG00000139549	ENSG00000185920
Uniprot IDs		O43323	Q13635 Q59FG5
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Epithelium Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Branching Morphogenesis Of An Epithelial Tube Neural Plate Axis Specification Response To Chlorate Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Epithelial Tube Morphogenesis Tube Morphogenesis Cell Proliferation Involved In Metanephros Development Pattern Specification Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Morphogenesis Of An Epithelium Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Regulation Of Signal Transduction Cellular Response To Cholesterol Neural Plate Development Cellular Response To Sterol Tissue Morphogenesis Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Tube Development Response To Cholesterol Pharyngeal System Development Cell Proliferation Regulation Of Cholesterol Efflux Dorsal/ventral Neural Tube Patterning Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein Targeting To Plasma Membrane Organ Morphogenesis Spinal Cord Motor Neuron Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Osteoblast Differentiation Embryonic Axis Specification Neuroblast Proliferation Ventral Spinal Cord Development Hindlimb Morphogenesis	Muscle Tissue Development Positive Regulation Of Cell Proliferation Smoothened Signaling Pathway Digestive Tract Development Digestive System Development Intein-mediated Protein Splicing Heart Development Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Organ Development Heart Looping Positive Regulation Of Hh Target Transcription Factor Activity Determination Of Heart Left/right Asymmetry Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Embryonic Heart Tube Morphogenesis Cell Fate Commitment Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Positive Regulation Of Stem Cell Proliferation Striated Muscle Tissue Development Tissue Development Muscle Cell Differentiation Embryonic Organ Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Cardiovascular System Development Cell Development Cell Differentiation Response To Organic Cyclic Compound Embryonic Heart Tube Development Cell-cell Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of Cell Death Epithelial-mesenchymal Cell Signaling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation
Tagcloud ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes hedgehog helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian shh sonic suggestions vertebrate vertebrates wgd	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Difference) ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes hedgehog helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian shh sonic suggestions vertebrate vertebrates wgd	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Intersection) ?